Resolution of Mephenytoin and Some Chiral Barbiturates into Enantiomers by Reversed Phase High Performance Liquid Chromatography via β-Cyclodextrin Inclusion Complexes
Resolution of Mephenytoin and Some Chiral Barbiturates into Enantiomers by Reversed Phase High Performance Liquid Chromatography via β-Cyclodextrin Inclusion Complexes
复制标题
通过反相高效液相色谱法通过 β-环糊精包合物将美芬妥英和一些手性巴比妥类药物拆分为对映体
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
J. Bojarşki
中科院分区：
文献类型：
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作者：
D. Sybilska;J. Żukowski;J. Bojarşki
摘要以β-环糊精为手性移动的相，在LiChrosorb RP 18柱上对美芬妥英和巴比妥类抗抑郁药进行了拆分。考察了β-环糊精浓度对容量因子的影响，计算了β-环糊精包合物的稳定常数和容量因子。已经发现，β-环糊精包合导致在嘧啶环中含有手性中心的美芬妥英和巴比妥类药物的情况下的明显的对映体选择性。根据影响分离度的两种现象：包合物在固定相上的吸附和在移动的相溶液中的络合过程，对结果进行了讨论。
Abstract β-Cyclodextrin as the chiral mobile phase component was used for resolution of mephenytoin and some barbiturates (antidepressant drugs) into enantiomers on LiChrosorb RP 18 column. The effects of β-cyclodextrin concentration on the capacity factors were investigated and the stability constants as well as capacity factors of β-cyclodextrin complexes were calculated. It has been found that β-cyclodextrin complexation results in a distinct enantioselectivity in the case of mephenytoin and barbiturates containing a chiral center in the pyrimidine ring. Results are discussed in the light of two phenomena influencing resolution: adsorption of inclusion complexes on the stationary phase and complexation process in the mobile phase solution.