Beyond central adiposity: Liver fat and visceral fat area are associated with metabolic syndrome in morbidly obese patients
Beyond central adiposity: Liver fat and visceral fat area are associated with metabolic syndrome in morbidly obese patients
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DOI：
10.1016/j.ijsu.2014.12.028
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发表时间：
2015-02-01
影响因子：
15.3
通讯作者：
Taveira-Gomes, A.
中科院分区：
文献类型：
--
作者：
Faria, G.;Goncalves, A.;Taveira-Gomes, A.
背景资料：尽管其广泛的临床应用，身体质量指数（BMI）和腰围已被报道为不准确的方法来衡量腹部肥胖。本研究的主要目的是确定内脏脂肪面积和脂肪肝浸润与代谢综合征（MS）在病态肥胖patients.Methods的表达之间的关系：我们招募了一个随机选择的100例病态肥胖患者的术前评估减肥手术。结果：MS患者的肝脏衰减值较低（中位数49.9 vs 55.5HU; p = 0.018），VAT较高（242 vs 172 cm（2）; p = 0.001）。常规测量（BMI：P = 0.729和腰围：P = 0.356），在鉴别病态肥胖MS患者中没有用。通过多变量logistic回归，脂肪肝浸润（OR = 5.3; P = 0.03）和年龄（OR = 1.08; p = .04）是与MS存在独立相关的唯一因素。脂肪肝和内脏肥胖患者的MS患病率分别为100%、71%和55%; 1;结论：CT扫描似乎可以测量MS的2个重要标志物：内脏脂肪过多和肝脏脂肪浸润。在病态肥胖患者中，内脏肥胖和肝脏脂肪浸润均会增加MS的风险。（C）2015 Surgical Associates Ltd.由Elsevier Ltd.出版。保留所有权利。
Background: Despite its widespread clinical use, both body mass index (BMI) and waist circumference have been reported as inaccurate methods to measure abdominal obesity. The main objective of this study was to determine the relation between visceral fat area and fatty liver infiltration with the expression of metabolic syndrome (MS) in morbidly obese patients.Methods: We recruited a random selection of 100 morbidly obese patients on pre-operative evaluation for bariatric surgery. A pre-operative CT slice at L4-L5 level, was performed to measure visceral fat and at T12 level to measure hepatic attenuation.Results: Patients with MS had lower hepatic attenuation values (median 49.9 vs 55.5HU; p = .018) and had more VAT (242 vs 172 cm(2); p = .001). Conventional measures (BMI: p = .729 and waist circumference: p = .356), were not useful in discriminating morbidly obese patients with MS. By multivariable logistic regression, fatty liver infiltration (OR = 5.3; p = .03) and age (OR = 1.08; p = .04) were the only factors independently related to the presence of MS. MS prevalence was 100%, 71% and 55%, respectively for patients with both fatty liver and visceral adiposity; one; or none of this findings (AUC -.715; p = .016).Conclusion: CT scan seems to measure 2 important markers of MS: visceral adiposity and hepatic fatty infiltration. In morbidly obese patients, both visceral adiposity and hepatic fatty infiltration increase the risk for the presence of MS. (C) 2015 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.