The geographic distribution of Loa loa in Africa: results of large-scale implementation of the Rapid Assessment Procedure for Loiasis (RAPLOA).
The geographic distribution of Loa loa in Africa: results of large-scale implementation of the Rapid Assessment Procedure for Loiasis (RAPLOA).
复制标题
DOI：
10.1371/journal.pntd.0001210
复制
发表时间：
2011-06
影响因子：
3.8
通讯作者：
Remme JH
中科院分区：
文献类型：
--
作者：
Zouré HG;Wanji S;Noma M;Amazigo UV;Diggle PJ;Tekle AH;Remme JH
在中部非洲，丝虫病是伊维菌素治疗控制盘尾丝虫病和消除淋巴丝虫病的主要障碍。在流行性支气管炎高水平的社区，伊维菌素治疗存在严重不良反应的显著风险。目前迫切需要关于非洲小蠊地理分布的资料，但现有资料有限。非洲盘尾丝虫病控制方案在11个可能流行的国家进行了大规模的盘尾丝虫病绘图，使用了盘尾丝虫病快速评估程序，该程序使用了关于眼蠕虫病史的简单调查表。RAPLOA调查在4798个村庄的空间样本中进行，覆盖面积为2500×3000 km，集中在非洲的洛伊托中心地带。调查显示，在10个国家中，估计有1440万人生活在高风险地区。RAPLOA数据之间有很强的空间相关性，克里金法被用来产生空间平滑的等值线图的内插流行的眼虫和预测概率的流行率超过40%。眼虫流行等值线图提供了第一个基于实际调查数据的全球范围内的眼虫分布图。它显示了一个明确的分布，有两个高度地方性的区域，大面积的地区是免费的loxidae和几个边界或中间地带。这些调查发现了几个以前未知的高流行病疫源地，澄清了中非共和国以及刚果共和国和刚果民主共和国大部分地区几乎没有任何信息的地方的流行性出血热分布，并确认了已知的流行性出血热疫源地。新的眼虫流行率地图和流行率超过40%风险阈值的概率为非洲数百万人的伊维菌素治疗计划提供了关键信息。Loa loa是一种被忽视的热带疾病，由丝虫寄生虫Loa loa感染引起，由寄生虫传播。当在高L的个体中报告神经系统严重不良事件（SAE）时，洛伐他汀最近已成为一种具有公共卫生重要性的疾病。伊维菌素治疗后的Loa微丝蚴血症。这对在与丝虫病同时流行的地区控制盘尾丝虫病和淋巴丝虫病产生了不利影响。20%的微丝蚴患病率被认为是阈值，超过该阈值，伊维菌素治疗的SAE风险不可接受。非洲盘尾丝虫病控制计划（APOC）在11个潜在流行国家进行了大规模的盘尾丝虫病绘图，使用了一种快速评估程序（RAPLOA），该程序使用了一份简单的调查问卷。对4798个抽样村庄的调查结果采用了一种称为克里金法的地统计分析方法，生成了眼虫流行的等高线图，提供了第一个基于实际调查数据的全球眼虫分布图。该地图显示了10个国家的高风险水平，估计有1440万人生活在高风险地区。
Loiasis is a major obstacle to ivermectin treatment for onchocerciasis control and lymphatic filariasis elimination in central Africa. In communities with a high level of loiasis endemicity, there is a significant risk of severe adverse reactions to ivermectin treatment. Information on the geographic distribution of loiasis in Africa is urgently needed but available information is limited. The African Programme for Onchocerciasis Control (APOC) undertook large scale mapping of loiasis in 11 potentially endemic countries using a rapid assessment procedure for loiasis (RAPLOA) that uses a simple questionnaire on the history of eye worm. RAPLOA surveys were done in a spatial sample of 4798 villages covering an area of 2500×3000 km centred on the heartland of loiasis in Africa. The surveys showed high risk levels of loiasis in 10 countries where an estimated 14.4 million people live in high risk areas. There was a strong spatial correlation among RAPLOA data, and kriging was used to produce spatially smoothed contour maps of the interpolated prevalence of eye worm and the predictive probability that the prevalence exceeds 40%. The contour map of eye worm prevalence provides the first global map of loiasis based on actual survey data. It shows a clear distribution with two zones of hyper endemicity, large areas that are free of loiasis and several borderline or intermediate zones. The surveys detected several previously unknown hyperendemic foci, clarified the distribution of loiasis in the Central African Republic and large parts of the Republic of Congo and the Democratic Republic of Congo for which hardly any information was available, and confirmed known loiasis foci. The new maps of the prevalence of eye worm and the probability that the prevalence exceeds the risk threshold of 40% provide critical information for ivermectin treatment programs among millions of people in Africa. Loiasis is a neglected tropical disease caused by infection with the filarial parasite Loa loa, transmitted by Chrysops vectors. Loiasis has recently emerged as a disease of public health importance when neurologic serious adverse events (SAEs) were reported in individuals with high L. loa microfilaraemia after ivermectin treatment. This had a negative impact on the control of onchocerciasis and lymphatic filariasis in areas of co-endemicity with loiasis. Microfilarial prevalence of 20% has been suggested as the threshold above which there is an unacceptable risk of SAEs with ivermectin treatment.The African Programme for Onchocerciasis Control (APOC) undertook large scale mapping of loiasis in 11 potentially endemic countries using a rapid assessment procedure for loiasis (RAPLOA) that uses a simple questionnaire on the history of eye worm. A geostatistical analysis method called kriging applied to the results in 4798 sampled villages generated a contour map of eye worm prevalence, providing the first global map of loiasis based on actual survey data. This map showed high risk levels of loiasis in 10 countries where an estimated 14.4 million people live in high risk areas.
登录
查看更多内容
DOI：
10.1016/0169-4758(96)40006-0
发表时间：
1996-11-01
期刊：
PARASITOLOGY TODAY
影响因子：
--
作者：
Chippaux, JP;Boussinesq, M;Ernould, JC
通讯作者：
Ernould, JC
DOI：
10.1179/136485913x13789813917463
发表时间：
2007-09-01
影响因子：
--
作者：
Diggle, P. J.;Thomson, M. C.;Molyneux, D. H.
通讯作者：
Molyneux, D. H.
影响因子：
9.4
作者：
Burbelo, Peter D.;Ramanathan, Roshan;Nutman, Thomas B.
通讯作者：
Nutman, Thomas B.
DOI：
10.1080/00034983.1953.11685587
发表时间：
1953-01-01
影响因子：
--
作者：
KERSHAW, WE;KEAY, RWJ;ZAHRA, A
通讯作者：
ZAHRA, A
DOI：
10.1198/016214507000001409
发表时间：
2008-03-01
影响因子：
3.7
作者：
Crainiceanu, Ciprian M.;Diggle, Peter J.;Rowlingson, Barry
通讯作者：
Rowlingson, Barry