Using Cherenkov imaging to monitor the match line between photon and electron radiation therapy fields on biological tissue phantoms.
Using Cherenkov imaging to monitor the match line between photon and electron radiation therapy fields on biological tissue phantoms.
复制标题
使用切伦科夫成像监测生物组织模型上光子和电子放射治疗场之间的匹配线
DOI：
10.1117/1.jbo.25.12.125001
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发表时间：
2020-12
影响因子：
3.5
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Li Y;Liu H;Huang N;Wang Z;Zhang C
重要性：由于乳腺癌放疗过程中患者的呼吸运动或不自主的身体运动，表面照射区域的不匹配相邻射野可能导致这些区域的剂量不足或过量，这将导致组织损伤、皮肤过度烧伤和潜在死亡。切伦科夫发光成像（CLI）可以有效地检测相邻辐射野的匹配信息，而无需额外的辐射或侵入性成像。目的：本研究的目的是为利用CLI技术监测放射治疗过程中由于引入位移而引起的光子场和电子场之间的相邻辐射场匹配提供生物学实验依据。方法：使用医用加速器产生光子和电子场。采用工业相机系统对黄色（A组和C组实验）或黑色（B组实验）照射鸡组织时激发的CLI信号进行成像。测试了以下引入的位移：朝向上级或下级方向10、5、2和0 mm。介绍了一个模型，用于处理相邻的辐射场的匹配误差分析，由于引入的偏移与调整计划，用于治疗右乳房肿瘤的锁骨上淋巴结或内乳淋巴结。结果：光子场与电子场的匹配值与实验测量的黄鸡辐照过程中引入的位移一致。在A组中，光子场和电子场在前/后（AP）方向上的平均差异为和，分别有87%和75%的测量值在1 mm以内。在C组中，对于倾斜光子野，机架角度为330 °和150 °，平均差异为和，分别有66%和65%的测量值在1 mm以内。平均差异为AP方向的电子场，94%的测量值在1 mm内。所提出的方法引入的匹配误差小于1.5毫米的AP领域和2毫米的斜入射领域。然而，由于在B组中很难从背景噪声中提取出弱CLI信号，因此不能用乌鸡组织照射来监测场匹配。结论：CLI被证明用于定量监测光生物组织模型上的场匹配线，并且具有在乳腺癌放疗期间监测表面组织中的场匹配的潜力。
Significance: Due to patients’ respiratory movement or involuntary body movements during breast cancer radiotherapy, the mismatched adjacent fields in surface exposure regions could result in insufficient dosage or overdose in these regions, which would lead to tissue injury, excessive skin burns, and potential death. Cherenkov luminescence imaging (CLI) could be used to effectively detect the matching information of adjacent radiation fields without extra radiation or invasive imaging. Aim: Our objective was to provide a biological experimental basis for monitoring matching of adjacent radiation fields between photon and electron fields due to introduced shifts during radiotherapy by CLI technique. Approach: A medical accelerator was used to generate photon and electron fields. An industrial camera system was adopted to image the excited CLI signal during irradiation of chicken tissue with yellow (group A and group C experiments) or black color (group B experiment). The following introduced shifts were tested: 10, 5, 2, and 0 mm toward superior or inferior direction. A model was introduced to deal with matching error analysis of adjacent radiation fields due to introduced shifts with adapted plans used to treat neoplasms of the right breast with supraclavicular nodes or internal mammary lymph node. Results: The matching values between photon and electron fields were consistent with the tested introduced shifts during yellow chicken irradiation. In group A, average discrepancies were and for photon fields and electron fields in anterior/posterior (AP) direction, with 87% and 75% of measurement within 1 mm, respectively. In group C, average discrepancies were and for oblique photon field with gantry angles of 330 deg and 150 deg, with 66% and 65% of measurement within 1 mm, respectively. The average discrepancies were for electron field in the AP direction, with 94% of measurement within 1 mm. The matching error introduced by the proposed method was less than 1.5 mm for AP fields and 2 mm for oblique incidence fields. However, the field matching could not be monitored with black chicken tissue irradiation due to a weak CLI signal that could hardly be extracted from background noise in group B. Conclusions: CLI is demonstrated for the quantitative monitoring of the field match line on light biological tissue phantoms and has potential for monitoring of field matching in surface tissue during breast cancer radiotherapy.