Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
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DOI：
10.1038/embor.2011.28
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发表时间：
2011-04-01
期刊：
影响因子：
7.7
通讯作者：
Yamamoto, Hiroshi
中科院分区：
文献类型：
--
作者：
He, Mei;Kubo, Hiroshi;Yamamoto, Hiroshi
凋亡细胞的清除对于组织发育、稳态和炎症的消退是必要的。凋亡细胞的摄取是由细胞表面上的“吃我”信号（如磷脂酰丝氨酸）启动的，吞噬细胞通过使用特异性受体识别该信号。在这项研究中，我们表明，可溶性形式的受体晚期糖基化终产物（AGEs）结合磷脂酰丝氨酸以及凋亡的胸腺细胞。RAGE缺陷型（Rage（-/-））肺泡巨噬细胞对凋亡胸腺细胞的吞噬功能受损，对凋亡中性粒细胞的清除功能受损。我们的研究结果表明，磷脂酰丝氨酸受体的功能，并协助清除凋亡细胞。
Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an 'eat-me' signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE-deficient (Rage(-/-)) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage(-/-) mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.