Growth, stool consistency and bone mineral content in healthy term infants fed sn-2-palmitate-enriched starter infant formula: A randomized, double-blind, multicentre clinical trial
Growth, stool consistency and bone mineral content in healthy term infants fed sn-2-palmitate-enriched starter infant formula: A randomized, double-blind, multicentre clinical trial
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DOI：
10.1016/j.clnu.2018.05.015
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发表时间：
2019-06-01
影响因子：
6.3
通讯作者：
Turck, Dominique
中科院分区：
文献类型：
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作者：
Beghin, Laurent;Marchandise, Xavier;Turck, Dominique
背景资料：母乳中的棕榈酸酯主要位于三酰甘油sn-2位，而婴儿配方食品中的棕榈酸酯主要位于sn-1和sn-3位。在消化过程中，sn-1和sn-3位的棕榈酸酯水解为游离棕榈酸，随后与钙络合形成不溶性皂;这可能部分解释了为什么配方奶粉喂养的婴儿比母乳喂养的婴儿大便更硬。这项大型（n = 488）随机、双盲、一项多中心试验调查了增加婴儿配方奶粉中sn-2棕榈酸酯含量是否能改善粪便稠度和骨矿物质含量（通过双能X射线吸收测定法测量），而不影响生长或健康。从近似1周龄到4个月大，婴儿仅喂养三种配方奶粉中的一种：i）对照配方奶粉（CF; 16%的总棕榈酸酯在sn-2; n = 162），（ii）实验配方1（EF 1;总棕榈酸酯的43%在sn-2; n = 166）或（iii）实验配方2结果：意向性治疗分析显示，两个EF组（与CF组相比）在2周龄、1月龄和2月龄时的粪便更软（p
Background: Palmitate in breast milk is predominantly located in the triacylglycerol sn-2 position, while infant formulae contain palmitate predominantly in the sn-1 and sn-3 positions. During digestion, palmitate in the sn-1 and sn-3 positions is hydrolyzed to free palmitic acid that can subsequently complex with calcium to form insoluble soaps; this may partially explain why formula-fed infants have harder stools than breast-fed infants.Methods: This large (n = 488) randomized, double-blind, multicentre trial investigated whether increasing the sn-2 palmitate content of infant formula improves stool consistency and bone mineral content (measured by dual-energy x-ray absorptiometry), without affecting growth or health. From similar to 1 week to 4 months of age, infants were exclusively fed one of three formulae: i) control formula (CF; 16% of total palmitate at sn-2; n = 162), (ii) experimental formula 1 (EF1; 43% of total palmitate at sn-2; n = 166) or (iii) experimental formula 2 (EF2; 51% of total palmitate at sn-2; n = 160).Results: Intention-to-treat analysis showed softer stools in both EF groups (vs. CF) at ages 2 weeks and 1 and 2 months (p