Cell surface actions of adriamycin.
Cell surface actions of adriamycin.
复制标题
阿霉素的细胞表面作用。
DOI：
10.1016/0163-7258(91)90060-y
复制
发表时间：
1991
影响因子：
13.5
通讯作者：
Tritton,TR
中科院分区：
文献类型：
--
作者：
Tritton,TR
阿霉素对细胞的结构和功能特性具有广泛的作用。这篇综述总结了药物调节细胞表面膜的能力的文献，并试图解决这样的行动如何与细胞毒性有关的问题。此外，我们考虑使用聚合物固定阿霉素分离细胞内的药物从质膜的影响，并显示这种方法是如何有助于解释阿霉素的药理学。最后，一系列的生物物理和光谱的方法来定义阿霉素双层相互作用的分子细节进行了调查，并使用的结果来讨论这种药物如何结合到膜的模型。
Adriamycin has a vast range of reported actions on the structural and functional properties of cells. This review summarizes the literature on the ability of the drug to modulate the cell surface membrane and attempts to address the question of how such actions could be linked to cytotoxicity. In addition, we consider the use of polymer immobilization of adriamycin to separate intracellular from plasma membrane effects of the drug, and show how this approach has been helpful in interpreting the pharmacology of adriamycin. Finally, a range of biophysical and spectroscopic approaches to defining the molecular details of adriamycin-bilayer interactions is surveyed, and the results used to discuss a model for how this antineoplastic agent binds to membranes.