Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program
Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program
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DOI：
10.1007/s12350-010-9225-3
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发表时间：
2010-08-01
影响因子：
2.4
通讯作者：
deKemp, Robert A.
中科院分区：
文献类型：
--
作者：
Klein, Ran;Renaud, Jennifer M.;deKemp, Robert A.
背景资料。静息和应激状态之间心肌血流的变化通常被用来诊断冠状动脉疾病。相对心肌灌注成像(MPI)是常规方法，而心肌血流量定量(MBF)可提高对早期疾病检测的敏感性。负荷流量与静息流量之比(S/R)及其差值(S-R)均被认为是检测心肌血流储备减少区域的一种手段。在这项研究中，我们描述了一种高度自动化的方法来计算左室心肌的局部和整体静息、负荷、S/R和S-R极图。我们使用两个随机数据集(n=30)对两个操作员(新手和专家)进行相关性分析和Bland-Altman重复性系数(RPC%)分析，测量操作员间和操作员内的可变性。与S/R相比，S-RMBF的操作者间依赖变异性更小(RPC%=5.0%比12.6%，P
Background. Changes in myocardial blood flow between rest and stress states are commonly used to diagnose coronary artery disease. Relative myocardial perfusion imaging (MPI) is used routinely while myocardial blood flow quantification (MBF) may improve the sensitivity for detection of early disease. The ratio of flow at stress and rest (S/R) and their difference (S-R) have both been proposed as a means to detect regions with reduced myocardial flow reserve (MFR). In this study, we describe a highly automated method to calculate regional and global rest, stress, S/R, and S-R polar maps of the left ventricle myocardium.Methods. We measured the inter- and intra-operator variability using two randomized datasets (n = 30 each) for each of two operators (novice and expert) with correlation and Bland-Altman reproducibility coefficient (RPC%) analyses.Results. S-R MBF had less inter- operator dependent variability than S/R (RPC% = 5.0% vs 12.6%, P