Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration
Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration
复制标题
DOI：
10.1128/aac.47.5.1766-1770.2003
复制
发表时间：
2003-05-01
影响因子：
4.9
通讯作者：
Coulthard, K
中科院分区：
文献类型：
--
作者：
Li, J;Milne, RW;Coulthard, K
采用特异性高效液相色谱法（HPLC）研究了5只大鼠静脉推注1 mg硫酸粘杆菌素/kg体重后血浆和尿液中粘杆菌素以及粘杆菌素A和B的药代动力学。未结合黏菌素A和B的药代动力学行为存在差异。本文首次报道了用HPLC法研究粘杆菌素及其两个主要组分的药代动力学。
The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.