Antibiotics - Past, present, and future
Antibiotics - Past, present, and future
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DOI：
10.1016/j.mcna.2006.06.007
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发表时间：
2006-11-01
影响因子：
5.9
通讯作者：
Khardori, Nancy
中科院分区：
文献类型：
--
作者：
Khardori, Nancy
除微生物病原体引起的疾病以外的疾病的药物治疗包括治疗宿主。在传染病治疗中，目标是清除宿主的病原体。因此，药物治疗是针对病原体的。由于第二个生命体参与了三角区，药物治疗受到病原体的性质，组织特异性以及最重要的是，它为生存而经历的变化的影响。抗菌药物治疗的历史已经清楚地表明，用于治疗感染的药物也是使它们在未来更难治疗的原因。保持抗菌剂有用的唯一方法是适当和明智地使用它们。
The drug therapy for diseases other than those caused by microbial agents involves treating the host. In infectious diseases therapy, the goal is to rid the host of the pathogen. Hence, drug therapy is aimed at the pathogen. Because a second living agent is involved in the triangle, drug therapy is affected by the pathogen's nature, its tissue specificity, and, most importantly, the changes it undergoes to survive. The history of antimicrobial therapy has clearly demonstrated that the drugs that are used to treat infections are also responsible for making them more difficult to treat in the future. The only way to keep antimicrobial agents useful is to use them appropriately and judiciously.