Short Communication: Phylogenetic Evidence of HIV-1 Transmission Between Adult and Adolescent Men Who Have Sex with Men.
Short Communication: Phylogenetic Evidence of HIV-1 Transmission Between Adult and Adolescent Men Who Have Sex with Men.
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简短的交流：男男性行为的成年和青少年男性之间 HIV-1 传播的系统发育证据。
DOI：
10.1089/aid.2016.0061
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发表时间：
2017
影响因子：
1.5
通讯作者：
Frenkel,Lisa
中科院分区：
文献类型：
--
作者：
Wolf,Elizabeth;Herbeck,JoshuaT;VanRompaey,Stephen;Kitahata,Mari;Thomas,Katherine;Pepper,Gregory;Frenkel,Lisa
在美国，HIV-1在年轻人，尤其是男男性行为者（MSM）中的发病率正在上升。我们的目的是更好地了解青少年HIV-1感染的模式，以帮助指导未来的预防干预。我们进行了一项结合流行病学和hiv -1基因序列数据的研究，这些数据来自2000年至2013年在华盛顿州西雅图感染hiv的成人和青少年的回顾性队列。青少年被定义为第一次接受HIV-1治疗时的13-24岁。重建最大似然系统发育树，以确定两个或更多个体的假定病毒传播聚类，然后对聚类与人口统计学和临床参数之间的关联进行多变量回归检验。该数据集包括来自1953个个体的3102个序列；确定了72个假定的传播聚集群，代表168人（8.6%）。MSM和MSM/静脉吸毒（IDU）与聚类呈正相关，aOR分别为3.18 （95% CI: 1.34 ~ 7.55）和2.59 （95% CI: 1.04 ~ 6.49）。非裔美国人种族与聚类呈负相关（aOR 0.54 95% CI: 0.32-0.91）。25组有一名青少年，5组有两名青少年。与青少年聚集在一起的其他个体主要是男性（95%），白人（85%），MSM（66%）或MSM/IDU(16%)，平均年龄较大（34岁比22岁；p< 0.01）。在这个西雅图队列中，HIV-1传播联系在白人男性青少年和老年男男性接触者之间被确定。针对年龄差异对的干预措施可能会减少青春期男性的HIV-1感染。
HIV-1 incidence among youth, especially men who have sex with men (MSM), is increasing in the United States. We aimed to better understand the patterns of adolescent HIV-1 acquisition, to help guide future prevention interventions. We conducted a study combining epidemiologic and HIV-1polsequence data from a retrospective cohort of HIV-infected adults and adolescents in Seattle, WA between 2000 and 2013. Adolescents were defined as 13–24 years of age at the time of first HIV-1 care. Maximum-likelihood phylogenetic trees were reconstructed to identify putative viral transmission clusters of two or more individuals, followed by multivariable regression tests of associations between clustering and demographic and clinical parameters. The dataset included 3,102 sequences from 1,953 individuals; 72 putative transmission clusters were identified, representing 168 individuals (8.6%). MSM and MSM/intravenous drug use (IDU) were positively associated with clustering, with aOR 3.18 (95% CI: 1.34–7.55) and 2.59 (95% CI: 1.04–6.49), respectively. African American race was negatively associated with clustering (aOR 0.54 95% CI: 0.32–0.91). Twenty-five clusters contained one adolescent and five clusters contained two adolescents. Other individuals who clustered with adolescents were predominantly male (95%), white (85%), and either MSM (66%) or MSM/IDU (16%), with a greater mean age (34 years vs. 22 years;p< .01). In this Seattle cohort, HIV-1 transmission linkages were identified between white male adolescents and older MSM adults. Interventions aimed at age-discrepant pairs may reduce HIV-1 infections in adolescent males.
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影响因子：
11.8
作者：
Aldous, Jeannette L.;Pond, Sergei Kosakovsky;Smith, Davey M.
通讯作者：
Smith, Davey M.
影响因子：
3.8
作者：
Fisher, Martin;Pao, David;Pillay, Deenan
通讯作者：
Pillay, Deenan
影响因子：
7.7
作者：
Kouyos, Roger D.;Rauch, Andri;Guenthard, Huldrych F.
通讯作者：
Guenthard, Huldrych F.
DOI：
10.1097/qai.0000000000000809
发表时间：
2015-12-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Oster AM;Wertheim JO;Hernandez AL;Ocfemia MC;Saduvala N;Hall HI
通讯作者：
Hall HI