DEFECTIVE PHAGOCYTOSIS OF ISOLATED ROD OUTER SEGMENTS BY RCS RAT RETINAL-PIGMENT EPITHELIUM IN CULTURE
DEFECTIVE PHAGOCYTOSIS OF ISOLATED ROD OUTER SEGMENTS BY RCS RAT RETINAL-PIGMENT EPITHELIUM IN CULTURE
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DOI：
10.1126/science.560718
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
SZAMIER, RB
中科院分区：
文献类型：
--
作者：
EDWARDS, RB;SZAMIER, RB
从正常大鼠培养的视网膜色素上皮细胞吞噬大量从正常和患有遗传性视网膜变性的RCS大鼠分离的杆外段片段。培养的RCS大鼠色素上皮很少摄入外节材料，虽然细胞延长细胞过程中的片段的任何类型。正常和RCS色素上皮吞噬聚苯乙烯球。RCS大鼠色素上皮细胞吞噬外节的机制明显存在缺陷。
Retinal pigment epithelium cultured from normal rats phagocytize large amounts of rod outer segment fragments isolated from normal and RCS rats with inherited retinal degeneration. Cultured RCS rat pigment epithelium rarely ingested outer segment material, although the cells extend cellular processes around fragments of either type. Normal and RCS pigment epithelium phagocytized polystyrene spheres. RCS rat pigment epithelial cells apparently contain a defect in the mechanism for phagocytizing outer segments.