Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer.
Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer.
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DOI：
10.18632/oncotarget.13052
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发表时间：
2017-05-23
期刊：
影响因子：
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通讯作者：
Nonomura N
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文献类型：
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作者：
Hayashi T;Fujita K;Tanigawa G;Kawashima A;Nagahara A;Ujike T;Uemura M;Takao T;Yamaguchi S;Nonomura N
据报道，全身炎症和免疫反应与进行性前列腺癌有关。在这项研究中，我们探讨了白细胞 (WBC) 和 C 反应蛋白 (CRP) 水平中哪些部分与高格里森评分前列腺癌相关。对 966 名怀疑患有前列腺癌的男性进行了前列腺穿刺活检。我们在活检前评估了年龄、血清前列腺特异性抗原 (PSA)、前列腺体积、白细胞计数、白细胞分数（中性粒细胞、淋巴细胞、单核细胞、嗜碱性粒细胞和嗜酸性粒细胞）以及 CRP 水平，以了解其与活检结果的关联。在所有男性中，553 名（57.2%）前列腺癌呈阳性，其中 421 名患有高格里森评分癌症（格里森评分≥7）。年龄、PSA、PSA密度（PSAD）、WBC血清单核细胞分数、单核细胞与淋巴细胞比率（MLR）和CRP与高格里森评分癌症显着相关（p<0.01）。多变量分析显示，年龄、PSA、PSAD 和血清单核细胞分数与高格里森评分前列腺癌显着相关（p <0.01）。在 571 名 PSA <10 ng/ml 的患者中，年龄、PSA、PSAD、血清 WBC 计数、中性粒细胞分数、单核细胞分数和 MLR 与高格里森评分前列腺癌显着相关（p<0.05）。多变量分析显示，年龄、PSAD 和血清单核细胞分数与高格里森评分前列腺癌显着相关（p<0.01）。高格里森评分前列腺癌患者的白细胞单核细胞分数增加，表明单核细胞与前列腺癌的进展存在相互作用。
Systemic inflammation and immune responses are reported to be associated with progressive prostate cancer. In this study, we explored which among the fractions of white blood cell (WBC) and C-reactive protein (CRP) level were associated with high Gleason score prostate cancer. Prostate needle biopsy was performed in 966 men with suspicion of prostate cancer. We assessed age, serum prostate-specific antigen (PSA), prostate volume, WBC count, fractions of WBCs (neutrophils, lymphocytes, monocytes, basophils, and eosinophils), and CRP level before biopsy for associations with biopsy findings. Among all men, 553 (57.2%) were positive for prostate cancer including 421 with high Gleason score cancer (Gleason score ≥7). Age, PSA, PSA density (PSAD), serum monocyte fraction of WBC, monocyte-to-lymphocyte ratio (MLR), and CRP were significantly associated with high Gleason score cancer (p<0.01). Multivariate analysis showed that age, PSA, PSAD, and serum monocyte fraction were significantly associated with high Gleason score prostate cancer (p <0.01). In 571 patients with PSA of <10 ng/ml, age, PSA, PSAD, serum WBC count, neutrophil fraction, monocyte fraction, and MLR were significantly associated with high Gleason score prostate cancer (p<0.05). Multivariate analysis showed that age, PSAD, and serum monocyte fraction were significantly associated with high Gleason score prostate cancer (p<0.01). The monocyte fraction of WBCs was increased in patients with high Gleason score prostate cancer, suggesting an interaction of monocytes with the progression of prostate cancer.