Potential neural embedding of parental social standing
Potential neural embedding of parental social standing
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DOI：
10.1093/scan/nsn003
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发表时间：
2008-06-01
影响因子：
4.2
通讯作者：
Cohen, Sheldon
中科院分区：
文献类型：
--
作者：
Gianaros, Peter J.;Horenstein, Jeffrey A.;Cohen, Sheldon
儿童期和青春期的社会经济劣势预示着心理和身体健康状况不佳，成年后会因重大疾病而过早死亡。然而，社会经济因素可能对健康和寿命产生发育影响的神经通路在很大程度上仍不清楚。这项功能磁共振研究提供了新的证据，证明了父母的社会地位相对较低的看法与杏仁核对威胁面部表情的更大反应之间的独特关系。这种关系无法用几个可能的混杂因素来解释，包括性别、种族、性格情绪性、抑郁和焦虑症状、父母教育以及参与者对自己社会地位的看法。杏仁核表现出显著的发育可塑性，在处理情绪信息、调节情绪相关行为和协调整个生命过程中的生物行为应激反应方面发挥着重要作用。因此，这些发现可能提供对影响健康中社会经济差异的神经发育途径的洞察。
Socioeconomic disadvantage during childhood and adolescence predicts poor mental and physical health and premature death by major medical diseases in adulthood. However, the neural pathways through which socioeconomic factors may exert a developmental influence on health and longevity remain largely unknown. This fMRI study provides novel evidence of a unique relationship between the perception that ones parents had a relatively low social standing-a putative indicator of early socioeconomic disadvantage-and greater amygdala reactivity to threatening facial expressions. This relationship was not explained by several possible confounders, including sex, ethnicity, dispositional emotionality, symptoms of depression and anxiety, parental education and participants perceptions of their own social standing. The amygdala expresses marked developmental plasticity and plays instrumental roles in processing emotional information, regulating emotion-related behaviors and orchestrating biobehavioral stress responses throughout life. Thus, these findings may provide insight into the neurodevelopmental pathways impacting socioeconomic disparities in health.