Sex differences in autoimmune diseases.
Sex differences in autoimmune diseases.
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DOI：
10.1186/2042-6410-2-1
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发表时间：
2011-01-04
影响因子：
7.9
通讯作者：
Voskuhl R
中科院分区：
文献类型：
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作者：
Voskuhl R
女性更容易患多种自身免疫性疾病，包括系统性红斑狼疮（SLE）、多发性硬化症（MS）、原发性胆汁性肝硬化、类风湿性关节炎和桥本甲状腺炎。与雄性相比，雌性的易感性增加也存在于自身免疫性疾病的动物模型中，例如 (NZBxNZW)F1 和 NZM.2328 小鼠的自发性 SLE、SJL 小鼠的实验性自身免疫性脑脊髓炎 (EAE)、MRL/Mp-lpr/lpr 小鼠的甲状腺炎、干燥综合征以及非肥胖糖尿病小鼠的糖尿病。事实上，与迄今为止发现的任何单一遗传或环境风险因素相比，女性患这些疾病的风险更大。了解女性的状态如何如此深刻地影响自身免疫性疾病的易感性将实现两个主要目标。首先，它将导致对疾病发病机制的主要途径的深入了解，其次，它可能会导致破坏这些途径的新疗法。
Women are more susceptible to a variety of autoimmune diseases including systemic lupus erythematosus (SLE), multiple sclerosis (MS), primary biliary cirrhosis, rheumatoid arthritis and Hashimoto's thyroiditis. This increased susceptibility in females compared to males is also present in animal models of autoimmune diseases such as spontaneous SLE in (NZBxNZW)F1 and NZM.2328 mice, experimental autoimmune encephalomyelitis (EAE) in SJL mice, thyroiditis, Sjogren's syndrome in MRL/Mp-lpr/lpr mice and diabetes in non-obese diabetic mice. Indeed, being female confers a greater risk of developing these diseases than any single genetic or environmental risk factor discovered to date. Understanding how the state of being female so profoundly affects autoimmune disease susceptibility would accomplish two major goals. First, it would lead to an insight into the major pathways of disease pathogenesis and, secondly, it would likely lead to novel treatments which would disrupt such pathways.