Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551.

Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551.
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地塞米松和暂时性营养不良对感染雾化结核分枝杆菌 CDC1551 的兔子的影响。

DOI:
10.1128/iai.73.10.7056-7060.2005
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发表时间:
2005
影响因子:
3.1
通讯作者:
Manabe,YukariC
Manabe,YukariC
中科院分区:
医学2区
文献类型:
--
作者:
Kesavan,AnupK;Mendez,SusanaE;Hatem,ChristineL;Lopez-Molina,Javier;Aird,Katherine;Pitt,MLouiseM;DannenbergJr,ArthurM;Manabe,YukariC

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Malnutrition is common in the developing world, where tuberculosis is often endemic. Rabbits infected with aerosolizedMycobacterium tuberculosisthat subsequently became inadvertently and transiently malnourished had compromised cell-mediated immunity comparable to that of the rabbits immunosuppressed with dexamethasone. They had significant leukopenia and reduced delayed-type hypersensitivity responses. Malnutrition dampened cell-mediated immunity and would interfere with diagnostic tests that rely on intact CD4 T-cell responses.
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