Catalysts for Fine Chemical Synthesis
Catalysts for Fine Chemical Synthesis
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DOI：
10.1002/0470855800
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发表时间：
2002-08
期刊：
影响因子：
--
通讯作者：
S. Roberts;G. Poignant
中科院分区：
文献类型：
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作者：
S. Roberts;G. Poignant
结论使用呋喃基氢过氧化物[1]促进了操作简单的程序，可替代Kagan [2]报道的程序。氧化反应进行迅速，并已获得非常高的ee，特别是在芳基甲基硫醚的情况下，而过量氧化成砜可以在很大程度上减少（< 3%）在所提出的实验条件。涉及使用不同手性配体（例如联萘[3]、2，2，5，5-四甲基-3，4-己二醇[4]、1，2-二芳基乙烷-1，2-二醇[5]）的改进的催化方法通常选择性较低，并且可以观察到非常可变的ees值。
ConclusionThe use of furylhydroperoxides [1] has facilitated an operationally simple procedure, alternative to the one reported by Kagan [2]. Oxidation takes place rapidly and very high ees have been obtained, especially in the case of aryl methyl sulfides, while overoxidation to sulfone can be reduced to a great extent (< 3%) under the proposed experimental conditions. Modified catalytic procedures involving the employment of different chiral ligands, such as binaphthol [3], 2, 2, 5, 5-tetramethyl-3, 4-hexanediol [4], 1, 2-diarylethane-1, 2-diols [5] are often less selective and very variable values of ees can be observed.