Polymeric Supra-amphiphiles Based on Terminal Group Electrostatic Interactions: Fabrication of Micelles with Modifiable Surfaces
Polymeric Supra-amphiphiles Based on Terminal Group Electrostatic Interactions: Fabrication of Micelles with Modifiable Surfaces
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基于末端基团静电相互作用的聚合物超两亲物：具有可修饰表面的胶束的制造
DOI：
10.1021/la501936a
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发表时间：
2014-07-29
期刊：
影响因子：
3.9
通讯作者：
Huang, Yong
中科院分区：
文献类型：
--
作者：
Liu, Zhi;Qiao, Jing;Huang, Yong
基于端基静电相互作用（TGEI），一端带有羧基的聚乳酸均聚物（PLA-COOH）与七-6-肼基-β-环糊精（HH-CD）形成超两亲物。两亲物在水溶液中可以自组装成胶束结构。由环糊精组成的胶束的外表面可以通过主客体相互作用进一步改性。考虑到构建块的生物相容性，进一步探索胶束在抗癌药物纳米载体中的应用。
On the basis of terminal group electrostatic interactions (TGEI), a supra-amphiphile is formed between a homopolymer of polylactic acid with carboxyl group at one end (PLA-COOH) and hepta-6-hydrazyl-beta-cyclodextrin (HH-CD). The amphiphile can self-assemble into a micellar structure in aqueous solution. The outer surface of the micelle, which is composed of cyclodextrins, can be further modified via host guest interactions. Considering the biocompatibility of the building blocks, the application of the micelles in a nanocarrier of anticancer drugs is further explored.