Avian influenza A (H9N2) virus infections among poultry workers, swine workers, and the general population in Beijing, China, 2013-2016: A serological cohort study
Avian influenza A (H9N2) virus infections among poultry workers, swine workers, and the general population in Beijing, China, 2013-2016: A serological cohort study
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DOI：
10.1111/irv.12641
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发表时间：
2019-07-01
影响因子：
4.4
通讯作者：
Wang, Quanyi
中科院分区：
文献类型：
--
作者：
Ma, Chunna;Cui, Shujuan;Wang, Quanyi
背景 很少有研究报告甲型禽流感 (H9N2) 病毒抗体的血清流行率以及中国北方和养猪工人中这些感染的发生率。方法 我们对中国北京从事家禽或猪工作的人员或一般人群进行了血清学队列研究。它包括 2013 年 11 月、2014 年 4 月、2015 年 4 月和 2016 年 4 月进行的四次横断面血清学调查。使用血凝抑制 (HI) 测定对从参与者收集的血液样本进行抗 H9N2 抗体检测。然后使用多变量泊松回归模型比较三组中H9N2病毒感染的人月发病率，并通过发病率比（IRR）进行评估。结果 4次横断面调查中，2016年4月禽类从业人员抗H9N2抗体（HI滴度≥80）血清阳性率最高（2.77%，19/685），2015年4月一般人群血清阳性率最低（0.09%，1/1135）。家禽工人（3.75/1000人月），其次是养猪工人（1.94/1000人月）和一般人群（1.78/1000人月）。多变量分析显示，家禽工人感染H9N2病毒的风险高于一般人群（IRR：2.42，95％CI：1.07-5.48；P = 0.034）。结论 虽然北京市H9N2抗体血清阳性率较低，但家禽从业人员感染H9N2病毒的风险高于普通人群。有必要对家禽工人进行更密切的监测并加强保护措施。
Background Few studies have reported on the seroprevalence of antibodies against avian influenza A (H9N2) virus and the incidence of these infections in the northern China and among swine workers. Methods We conducted a serological cohort study among people working with poultry or swine or the general population in Beijing, China. It comprised four cross-sectional serological surveys in November 2013, April 2014, April 2015, and April 2016. Blood samples collected from the participants were tested for anti-H9N2 antibodies using a hemagglutination-inhibition (HI) assay. Multivariable Poisson regression model was then used to compare the person-month incidence rates for H9N2 viral infections among the three groups, assessed by incidence rate ratio (IRR). Results In the four cross-sectional surveys, the highest seroprevalence of anti-H9N2 antibodies (HI titer >= 80) was recorded in the poultry workers (2.77%, 19/685) in April 2016, while the lowest was recorded in the general population (0.09%, 1/1135) in April 2015. The highest incidence density rate for H9N2 infections across the whole study period was recorded among the poultry workers (3.75/1000 person-months), followed by the swine workers (1.94/1000 person-months) and the general population (1.78/1000 person-months). Multivariable analysis showed that the poultry workers were at higher risk (IRR: 2.42, 95% CI: 1.07-5.48; P = 0.034) of contracting H9N2 virus than the general population. Conclusions Although the seroprevalence of H9N2 antibodies was low in Beijing, the poultry workers were at higher risk of contracting H9N2 viral infections than the general population. Closer monitoring and strengthened protection measures for poultry workers are warranted.