Effect of 25-Hydroxyvitamin D Status on Serological Response to Influenza Vaccine in Prostate Cancer Patients
Effect of 25-Hydroxyvitamin D Status on Serological Response to Influenza Vaccine in Prostate Cancer Patients
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DOI：
10.1002/pros.21250
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发表时间：
2011-03-01
期刊：
影响因子：
2.8
通讯作者：
Trump, Donald
中科院分区：
文献类型：
--
作者：
Chadha, Manpreet K.;Fakih, Marwan;Trump, Donald
背景资料。流行病学数据表明，维生素D缺乏与流感感染有关。我们进行了一项前瞻性流感疫苗接种研究，以确定维生素D状态对前列腺癌(CAP)患者流感疫苗血清学应答的影响。方法：在2006-2007年流感季节，罗斯威尔公园癌症研究所治疗的CAP患者在接种疫苗前和接种后3个月分别接种三价流感疫苗(Fluzone(R)，2006,2007)和血凝抑制(HI)效价测定的血清。对接种疫苗的反应被定义为对三种毒株中的任何一种在3个月内滴度=1：40或滴度增加四倍。用DiaSorin I-125放射免疫试剂盒检测血清25-羟基维生素D(25-D-3)水平。结果：35例CAP患者参与研究。中位基线25-D-3水平为44.88 ng/ml(范围为9.16-71.98 ng/ml)，对这三种毒株中的任何一种均有80%的血清学反应。当将基线25-D3水平作为连续变量测试时，对血清学反应有显著影响(P=0.0446)。25-D3水平上四分位数的所有患者均有血清学应答(P=0.0344)。其他基线变量(年龄、种族、化疗状态或白细胞计数)均未对血清学应答产生影响。结论：在这项研究中，CAP患者体内维生素D充足的状态与流感疫苗的血清学应答频率更高有关。前列腺癌71：368-372,2011年。(C)2010年Wiley-Liss公司
BACKGROUND. Epidemiologic data suggest that there is an association between vitamin D deficiency and influenza infection. We conducted a prospective influenza vaccination study to determine the influence of vitamin D status on serological response to influenza vaccine in prostate cancer (CaP) patients.METHODS. During the 2006-2007 influenza season, CaP patients treated at Roswell Park Cancer Institute were offered vaccination with the trivalent influenza vaccine (Fluzone (R), 2006 2007) and sera collected for hemagglutination inhibition (HI) assay titers before and 3 months after vaccination. Response to vaccination was defined as >= 1:40 titer ratio or a fourfold increase in titer at 3 months, against any of the three strains. Serum 25-hydroxyvitamin D (25-D-3) levels were measured using DiaSorin I-125 radioimmunoassay kits.RESULTS. Thirty-five patients with CaP participated in the study. Median baseline 25-D-3 level was 44.88 ng/ml (range: 9.16-71.98 ng/ml) Serological response against any of the three strains was noted in 80%. There was a significant effect of baseline 25-D3 level when tested as a continuous variable in relation to serological response (P = 0.0446). All patients in the upper quartile of 25-D3 level responded by mounting a serological response (P = 0.0344). None of the other baseline variables (age, race, chemotherapy status, or white cell count) had an effect on serological response.CONCLUSIONS. In this study in CaP patients, a replete vitamin D status was associated with more frequent serological response to influenza vaccine. Prostate 71: 368-372, 2011. (C) 2010 Wiley-Liss, Inc.