Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the JAK/STAT signal transduction pathway in Drosophila
Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the JAK/STAT signal transduction pathway in Drosophila
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DOI：
10.1016/s1534-5807(03)00024-8
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发表时间：
2003-02-01
影响因子：
11.8
通讯作者：
Hou, SX
中科院分区：
文献类型：
--
作者：
Chen, X;Oh, SW;Hou, SX
The JAK/STAT signal transduction pathway regulates many developmental processes in Drosophila. However, the functional mechanism of this pathway is poorly understood. In this report, we identify the Drosophila cyclin-dependent kinase 4 (Cdk4), which exhibits embryonic mutant phenotypes identical to those in the Hopscotch/JAK kinase and stat92E/STAT mutations. Specific genetic interactions between Cdk4 and hop mutations suggest that Cdk4 functions downstream of the HOP tyrosine kinase. We further show that Cyclin D-Cdk4 (as well as Cyclin E-Cdk2) binds and regulates STAT92E protein stability. STAT92E regulates gene expression for various biological processes, including the endocycle S phase. These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development.
