Structure and Function of G Protein Coupled Receptors
Structure and Function of G Protein Coupled Receptors
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DOI：
10.1023/a:1015969301407
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发表时间：
1990-12
影响因子：
3.7
通讯作者：
J. Lameh;R. Cone;S. Maeda;M. Philip;M. Corbani;L. Nádasdi;J. Ramachandran;Graham M. Smith;
中科院分区：
文献类型：
--
作者：
J. Lameh;R. Cone;S. Maeda;M. Philip;M. Corbani;L. Nádasdi;J. Ramachandran;Graham M. Smith;
G蛋白偶联受体(GPC-Rs)由一个编码众多受体的基因超家族组成，这些受体都具有共同的结构特征，例如7个假定的跨膜结构域。它们的生物学功能极其多样，从视觉和嗅觉到神经和内分泌信号。GPC-Rs通过多个G蛋白与越来越多的已知第二信使途径偶联，如cAMP和磷脂酰肌醇的代谢。本文综述了GPC-R激活第二信使系统的分子机制，并对其调控和结构进行了综述。
The G protein coupled receptors (GPC-Rs) comprise a large superfamily of genes encoding numerous receptors which all show common structural features, e.g., seven putative membrane spanning domains. Their biological functions are extremely diverse, ranging from vision and olfaction to neuronal and endocrine signaling. The GPC-Rs couple via multiple G proteins to a growing number of recognized second messenger pathway, e.g., cAMP and phosphatidyl inositol turnover. This review summarizes our current knowledge of the molecular mechanisms by which the GPC-Rs activate second messenger systems, and it addresses their regulation and structure.