Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
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DOI：
10.1101/cshperspect.a021907
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发表时间：
2016-06-01
影响因子：
7.2
通讯作者：
Rifkin, Daniel B.
中科院分区：
文献类型：
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作者：
Robertson, Ian B.;Rifkin, Daniel B.
转化生长因子β (TGF-β) 家族成员的生物利用度受多种机制控制。真正的 TGF-β 以潜伏状态隔离在基质中，必须先被激活，然后才能与其受体结合。在这里，我们回顾了调节 TGF-β 生物利用度的分子和机制，并将这些机制与用于调节其他 TGF-β 家族成员的机制进行比较。我们还通过检查来自敲除小鼠模型和其他生物系统的可用体内数据，评估各种潜在 TGF-β 激活剂以及 TGF-β 家族信号传导的其他细胞外调节剂的生理意义。
The bioavailability of members of the transforming growth factor beta (TGF-beta) family is controlled by a number of mechanisms. Bona fide TGF-beta is sequestered into the matrix in a latent state and must be activated before it can bind to its receptors. Here, we review the molecules and mechanisms that regulate the bioavailability of TGF-beta and compare these mechanisms with those used to regulate other TGF-beta family members. We also assess the physiological significance of various latent TGF-beta activators, as well as other extracellular modulators of TGF-beta family signaling, by examining the available in vivo data from knockout mouse models and other biological systems.