Blood velocity and volumetric flow rate in human retinal vessels.
Blood velocity and volumetric flow rate in human retinal vessels.
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DOI：
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发表时间：
1985-08
影响因子：
4.4
通讯作者：
C. Riva;J. Grunwald;S. Sinclair;B. Petrig
中科院分区：
文献类型：
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作者：
C. Riva;J. Grunwald;S. Sinclair;B. Petrig
正常人视网膜各血管的血流速度和体积流量的分布被确定为血管直径的函数。根据双向激光多普勒测速仪（LDV）测量的中心线速度计算血液的平均速度Vmean。体积流速由Vmean确定，血管直径D由单色眼底照片测量。LDV测量部位的动脉和静脉直径范围分别为39至134微米和64至177微米。血流速度与D相关（动脉和静脉P均小于0.001）。体积流速随D变化，动脉的幂为2.76 +/- 0.16，静脉的幂为2.84 +/- 0.12，与Murray定律非常一致。从12只眼睛计算，平均总动脉和静脉体积流速分别为33 +/- 9.6和34 +/- 6.3微升/分钟。两种流速之间的良好一致性表明，用于计算流量的技术和假设产生满足质量守恒的结果。总动脉和静脉体积流速与总动脉和静脉血管横截面相关。颞侧视网膜的体积流率明显大于鼻侧视网膜，但这种差异可能是由于颞侧视网膜的面积较大。在视网膜上级半球和下半球之间未观察到流速差异。最后，在正常实验条件下测量的主要视网膜血管中的血流速度在短（小时）和长（月）时间段内表现出显著恒定。
The distributions of blood velocity and volumetric flow rate in individual vessels of the normal human retina were determined as a function of vessel diameter. The mean velocity of blood, Vmean, was calculated from the centerline velocity measured by bidirectional laser Doppler velocimetry (LDV). Volumetric flow rate was determined from Vmean and the vessel diameter, D, measured from monochromatic fundus photographs. Diameter of the arteries and veins at the site of the LDV measurements ranged from 39 to 134 microns and 64 to 177 microns, respectively. Flow velocity correlated with D (P less than 0.001 for both arteries and veins). Volumetric flow rate varied with D at a power of 2.76 +/- 0.16 for arteries and 2.84 +/- 0.12 for veins, in close agreement with Murray's law. Calculated from 12 eyes, the average total arterial and venous volumetric flow rates were 33 +/- 9.6 and 34 +/- 6.3 microliters/min, respectively. The good agreement between both flow rates suggests that the technique and the assumptions for calculating flow yield results that satisfy mass conservation. Total arterial and venous volumetric flow rates correlated with total arterial and venous vessel cross-section. Volumetric flow rate in the temporal retina was significantly greater than in the nasal retina, but the difference is likely to be due to the larger area of the temporal retina. No difference in flow rate was observed between the superior and inferior retinal hemispheres. Finally, blood velocity in the major retinal vessels measured under normal experimental conditions appears remarkably constant over short (hours) and long (months) periods of time.