Effect of primary tumour volumes in early T-stage nasopharyngeal carcinoma
Effect of primary tumour volumes in early T-stage nasopharyngeal carcinoma
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DOI：
10.2310/7070.2003.37253
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发表时间：
2003-04-01
期刊：
影响因子：
--
通讯作者：
Hwang, KL
中科院分区：
文献类型：
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作者：
Chang, CC;Chen, MK;Hwang, KL
目的：探讨早期t期鼻咽癌原发性输注量与治疗效果的关系。设计：回顾性研究。环境：三级医疗中心。方法：对52例新确诊的早期t期鼻咽癌患者行高剂量放疗。主要结果测量：计算层析所得的初级道岔体积是根据面积技术的求和得到的。根据T分期和初发道岔量分析肿瘤相关生存率。结果：T1病、T2a病、T2b病的初发容积中位数分别为5.48 mL、17.95 mL、19.15 mL， T1病3.23 ~ 9.65 mL、T2a病6.31 ~ 64.54 mL、T2b病11.27 ~ 131.82 mL。大的原发性投票率与明显较差的疾病特异性生存率相关（p = 0.0003），而分为T2a和T2b的T期没有预后意义（p = 0.441）。结论：在T2a和T2b阶段，初级投票率存在实质性变化，初级投票率是一个更重要的预后因素。早期t期鼻咽癌原发肿瘤的体积测量可以更好地完善预后、淋巴结、转移分期系统。原发性投票率大的患者应更积极地治疗。
Objective: To investigate the relationship between primary turnout volumes and treatment outcomes in early T-stage nasopharyngeal carcinoma.Design: Retrospective study.Setting: Tertiary care centre.Method: A consecutive series of 52 newly diagnosed patients of early T-stage nasopharyngeal carcinoma who were treated with high-dose radiotherapy.Main Outcome Measures: Computed tomography-derived primary turnout volume was obtained following the summation of area technique. The cancer-related survival according to T stage and primary turnout volumes was analyzed.Results: The median primary turnout volume was 5.48 mL in T1 disease, 17.95 mL in T2a disease, and 19.15 mL in T2b disease, with a range of 3.23 to 9.65 mL in T1 disease, 6.31 to 64.54 mL in T2a disease, and 11.27 to 131.82 mL in T2b disease. Large primary turnout volume was associated with a significantly poor disease-specific survival (p = .0003), whereas the T stage that segregated into T2a and T2b carried no prognostic significance (p = .441).Conclusions: A substantial variation of primary turnout volume was present within the T2a and T2b stages, and primary turnout volume represented a more important prognostic factor. Volumetric measurements of primary tumours in early T-stage nasopharyngeal tumours would better refine the turnout, node, metastasis staging system. Patients with large primary turnout volume should be treated more aggressively.