PET quantitation and imaging of the non-pure positronemitting iodine isotope 124I
PET quantitation and imaging of the non-pure positronemitting iodine isotope 124I
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DOI：
10.1016/s0969-8043(01)00283-4
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发表时间：
2002-05-01
影响因子：
1.6
通讯作者：
Coenen, HH
中科院分区：
文献类型：
--
作者：
Herzog, H;Tellmann, L;Coenen, HH
一系列的PET研究使用的幻影提出表征成像和定量性能的正电子发射碘同位素I-124。测量在2D-PET扫描仪GE 4096 +和西门子PET扫描仪HR+上进行，可在2D和3D模式下操作。对与正电子一起发射的伽马射线没有特别的校正。与F-18相比，在使用I-124的研究中，图像分辨率和对比度略有下降，背景色有所增加。定量结果在不同的扫描仪和不同的采集和重建模式之间有所不同，在伽马射线能谱测量的幻影放射性方面，平均相对差异为-6 +/- 13%（平均+/- sd）。我们得出结论，用I-124标记的放射性药物的定量是可行的，并且可以通过开发特定的校正来改进。(C) 2002 Elsevier Science Ltd.版权所有。
A series of PET studies using phantoms is presented to characterize the imaging and quantitative performance of the positron-emitting iodine isotope I-124. Measurements were performed on the 2D-PET scanner GE 4096 + as well as on the Siemens PET scanner HR+ operated in both 2D and 3D modes. No specific correction was applied for the gamma-rays emitted together with the positrons. As compared to F-18, in studies with I-124 there is a small loss of image resolution and contrast, and an increase in background. The quantitative results varied between different scanners and various acquisition as well as reconstruction modes, with an average relative difference of -6 +/- 13% (mean+/-SD) in respect of the phantom radioactivity as measured with gamma-ray spectroscopy. We conclude that quantitation of a radiopharmaceutical labelled with I-124 is feasible and may be improved by the development of specific corrections. (C) 2002 Elsevier Science Ltd. All rights reserved.