NEW ANTIFUNGAL ANTIBIOTICS, PRADIMICIN-D AND PRADIMICIN-E - GLYCINE ANALOGS OF PRADIMICIN-A AND PRADIMICIN-C
NEW ANTIFUNGAL ANTIBIOTICS, PRADIMICIN-D AND PRADIMICIN-E - GLYCINE ANALOGS OF PRADIMICIN-A AND PRADIMICIN-C
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DOI：
10.7164/antibiotics.43.771
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发表时间：
1990-07-01
影响因子：
3.3
通讯作者：
OKI, T
中科院分区：
文献类型：
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作者：
SAWADA, Y;NISHIO, M;OKI, T
从木槿马杜拉放线菌（Actinomadura hibisca）P157-2（ATCC 53557）及其突变株A2660（ATCC 53762）的培养物中分离得到新的抗真菌抗生素普拉米菌素D和E。普拉米星D的结构是N-[[5S，6S）-5-O-[4，6-二脱氧-4-（甲氨基）-3-O-（β- D-吡喃木糖基）-β- D-吡喃半乳糖基]-5，6，8，13-四氢-1，6，9，14-四羟基-11-甲氧基-3-甲基-8，13-二氧代苯并[a]并四苯-2-基]羰基]甘氨酸，基于与普拉米星A相比的光谱分析。普拉米星E是普拉米星D的脱N-甲基类似物。普拉米星D和E在体外抗多种真菌和体内抗小鼠白色念珠菌A9540的活性与普拉米星A相同。
New antifungal antibiotics pradimicins D and E were isolated from the culture filtrates of Actinomadura hibisca P157-2 (ATCC 53557) and its mutant A2660 (ATCC 53762). The structure of pradimicin D is N-[[5S,6S)-5-O-[4,6-dideoxy-4-(methylamino)-3-O-(.beta.-D-xylopyranosyl)-.beta.-D-galactopyranosyl]-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo[a]naphthacen-2-yl]carbonyl]glycine, based on spectral analyses compared to pradimicin A. Pradimicin E is the des-N-methyl analog of pradimicin D. Pradimicins D and E were equal in activity to pradimicin A in vitro against a variety of fungi and in vivo against Candida albicans A9540 in mice.