Recent advance in antigen-specific immunotherapy for acute myeloid leukemia.
Recent advance in antigen-specific immunotherapy for acute myeloid leukemia.
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DOI：
10.1155/2011/104926
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发表时间：
2011
影响因子：
--
通讯作者：
Kitawaki T
中科院分区：
文献类型：
--
作者：
Kadowaki N;Kitawaki T
大多数急性髓系白血病（AML）患者化疗后复发是不可避免的。因此，有必要开发具有不同抗白血病机制的新疗法。免疫学和有希望的白血病相关抗原的鉴定的最新进展为化疗后通过抗原特异性免疫疗法根除微小残留病开辟了可能性。 AML 的免疫疗法有多种：肽疫苗、粒细胞-巨噬细胞集落刺激因子分泌肿瘤疫苗、树突状细胞疫苗和过继性 T 细胞疗法。尽管这些试验中的免疫原性和临床结果正在改善，但在高度热衷的工程 T 细胞疗法中观察到了严重的不良事件，这表明先进免疫疗法中有效性和副作用之间平衡的重要性。在诱导抗肿瘤免疫反应方面取得的进展，加上减弱免疫抑制因素的策略，将使免疫疗法成为对抗 AML 的重要武器。
Relapse after chemotherapy is inevitable in the majority of patients with acute myeloid leukemia (AML). Thus, it is necessary to develop novel therapies that have different antileukemic mechanisms. Recent advances in immunology and identification of promising leukemia-associated antigens open the possibilities for eradicating minimal residual diseases by antigen-specific immunotherapy after chemotherapy. Several methods have been pursued as immunotherapies for AML: peptide vaccines, granulocyte-macrophage colony-stimulating factor-secreting tumor vaccines, dendritic cell vaccines, and adoptive T cell therapy. Whereas immunogenicity and clinical outcomes are improving in these trials, severe adverse events were observed in highly avid engineered T cell therapies, indicating the importance of the balance between effectiveness and side effects in advanced immunotherapy. Such progress in inducing antitumor immune responses, together with strategies to attenuate immunosuppressive factors, will establish immunotherapy as an important armament to combat AML.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
20.3
作者：
Kochenderfer, James N.;Wilson, Wyndham H.;Rosenberg, Steven A.
通讯作者：
Rosenberg, Steven A.
影响因子：
20.3
作者：
Gaiger, A;Reese, V;Cheever, MA
通讯作者：
Cheever, MA
影响因子：
20.3
作者：
Gao, LQ;Bellantuono, I;Stauss, HJ
通讯作者：
Stauss, HJ
影响因子：
20.3
作者：
Goodyear, Oliver;Agathanggelou, Angelo;Craddock, Charles
通讯作者：
Craddock, Charles