Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway
Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway
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DOI：
10.1016/j.febslet.2009.12.019
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发表时间：
2010-02-19
期刊：
影响因子：
3.5
通讯作者：
Cheong, JaeHun
中科院分区：
文献类型：
--
作者：
Kim, KyeongJin;Kim, Kook Hwan;Cheong, JaeHun
咖喱香料姜黄素中的一种多酚化合物姜黄素已知对流感病毒、腺病毒、柯萨奇病毒和人类免疫缺陷病毒具有抗病毒活性。然而，姜黄素是否能抑制丙型肝炎病毒(HCV)的复制仍有待确定。在这项研究中，我们发现姜黄素通过抑制Akt-SREBP-1的激活而降低了丙型肝炎病毒基因的表达，而不是通过核因子-kappaB途径。姜黄素和干扰素联合应用对丙型肝炎病毒复制有明显的抑制作用。总之，我们的结果表明，姜黄素在体外可以抑制丙型肝炎病毒的复制，并可能作为新型的抗丙型肝炎病毒试剂。(C)2009年欧洲生化学会联合会。爱思唯尔出版公司版权所有。
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-kappa B pathway. The combination of curcumin and IFN alpha exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.