Alcohol screening scores and all-cause mortality in male Veterans Affairs patients.
Alcohol screening scores and all-cause mortality in male Veterans Affairs patients.
复制标题
男性退伍军人事务部患者的酒精筛查分数和全因死亡率。
DOI：
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发表时间：
2009
影响因子：
3.4
通讯作者：
K. Bradley
中科院分区：
文献类型：
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作者：
L. Kinder;C. Bryson;Haili Sun;E. Williams;K. Bradley
客观化
广泛的研究表明，酒精消费的深度访谈措施与死亡率之间存在J型或U型关联。关于酒精筛查问卷和死亡率之间的关系，人们知之甚少。这项研究调查了酒精使用障碍识别测试-消费三项问卷(AUDIT-C)的分数(范围从0到12)与死亡率之间的关系。
方法
这项队列研究包括来自7个退伍军人事务部(VA)医疗中心的男性门诊患者，他们完成了邮寄调查(1997-2000；n=34,292)的AUDIT-C，并平均跟踪了2.5年。死亡是从退伍军人管理局的数据库中确定的。
结果
在调整了人口统计学因素的分析中，AUDIT-C评分和全因死亡率之间观察到了U型关系。不饮酒者(AUDIT-C0)和大量饮酒者(AUDIT-C8-9和10-12)与酒精滥用筛查阴性者(AUDIT-C1-3)相比，死亡风险分别增加：危险比(HR)=1.41(95%可信区间：1.29-1.54)、1.32(1.03-1.69)和1.47(1.14-1.91)。这种关联在不同的年龄组中有所不同(p=0.003)。对于50岁以下男性，AUDIT-C评分10-12与死亡率增加相关(HR=2.21，95%CI：1.29-3.77)，而对于50岁及以上男性，自我报告戒酒(AUDIT-C0)与死亡率增加相关，而饮酒者AUDIT-C评分1-3：HR Formen50-=1.45(1.19-1.77)；65岁及以上男性HR=1.42(1.28-1.58)。
结论
观察到AUDIT-C与死亡率之间呈U型关系，不同年龄组之间有重要差异。这是第一项证明酒精使用的临床规模筛查措施与流行病学研究中观察到的更长措施的死亡率相似的相关性的研究。
OBJECTIVE
Extensive research demonstrates a J- or U-shaped association between in-depth interview measures of alcohol consumption and mortality. Little is known about the relationship between alcohol screening questionnaires and mortality. This study examined the association between scores (ranging from 0 to 12) on the three-item Alcohol Use Disorder Identification Test-Consumption Questionnaire (AUDIT-C) and mortality.
METHOD
This cohort study included male outpatients from seven Veterans Affairs (VA) medical centers who completed the AUDIT-C on mailed surveys (1997-2000; n=34,292) and who were followed for a mean of 2.5 years. Death was ascertained from VA databases.
RESULTS
In analyses adjusted for demographics, a U-shaped relationship was observed between AUDIT-C scores and all-cause mortality. Nondrinkers (AUDIT-C 0) and heavy drinkers (AUDIT-C 8-9 and 10-12) had increased risk of death compared with drinkers who screened negative for alcohol misuse (AUDIT-C 1-3): hazard ratios (HR)=1.41 (95% confidence interval [CI]: 1.29-1.54), 1.32 (1.03-1.69), and 1.47 (1.14-1.91), respectively. This association differed across age groups (p=.003). For men younger than 50 years, AUDIT-C scores 10-12 were associated with increased mortality (HR=2.21, 95% CI: 1.29-3.77), whereas for men age 50 or older, self-reported abstinence (AUDIT-C 0) was associated with increased mortality, compared with drinkers with AUDIT-C scores 1-3: HR formen 50-64=1.45 (1.19-1.77); HR for men 65 or older=1.42 (1.28-1.58).
CONCLUSIONS
A U-shaped association between the AUDIT-C and mortality was observed, with important differences by age group. This is the first study to demonstrate that a clinical scaled screening measure of alcohol use has a similar association with mortality to that observed in epidemiological research with lengthier measures.