Pyridoxine, Levodopa, and L-α-Methyldopa Hydrazine Regimen in Parkinsonism
Pyridoxine, Levodopa, and L-α-Methyldopa Hydrazine Regimen in Parkinsonism
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吡哆醇、左旋多巴和 L-α-甲基多巴肼疗法治疗帕金森病
DOI：
10.1001/jama.1971.03180390051016
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
R. Duvoisin
中科院分区：
文献类型：
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作者：
M. Yahr;R. Duvoisin
致编辑在这些专栏中出现了一些关于吡哆醇在用左旋多巴治疗的帕金森病患者中的作用的通讯。我们的初步观察1，摄入吡哆醇抵消了左旋多巴对帕金森综合征症状的有益作用，这一点已被Cotzias和Jameson证实2，3。然而，我们无法发现正常饮食摄入吡哆醇会干扰左旋多巴，也没有发现临床或实验室证据支持一些人表达的担忧4，5，长期给予该药剂可诱导吡哆醇缺乏状态。在我们持续的研究中，以提高左旋多巴的治疗价值，直到最近，我们发现吡哆醇的用途很少。虽然它可以用于控制左旋多巴的主要副作用之一，即异常的不自主运动，但这种理想的结果只能以牺牲
To the Editor.— A number of communications have appeared in these columns regarding the role of pyridoxine in patients with Parkinson's disease treated with levodopa. Our initial observation 1 that the ingestion of pyridoxine nullifies the beneficial effects of levodopa on the symptoms of parkinsonism has been confirmed by Cotzias and Jameson 2,3 However, we have been unable to find that the normal dietary intake of pyridoxine interfers with levodopa nor have we found clinical or laboratory evidence to support the fears expressed by some 4,5 that the long-term administration of this agent may induce a pyridoxine deficiency state. In our continuing investigations to improve the therapeutic value of levodopa, until recent date, we have found little use for pyridoxine. Though it can be used to control one of the major side effects of levodopa, namely, the abnormal involuntary movements, 5 this desirable result is achieved only at the expense of