Prognostic impact of MYH9 expression on patients with acute myeloid leukemia.
Prognostic impact of MYH9 expression on patients with acute myeloid leukemia.
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MYH9表达对急性髓系白血病患者预后的影响
DOI：
10.18632/oncotarget.10613
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发表时间：
2017-01-03
期刊：
影响因子：
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通讯作者：
Jin J
中科院分区：
文献类型：
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作者：
Yu M;Wang J;Zhu Z;Hu C;Ma Q;Li X;Yin X;Huang J;Zhang T;Ma Z;Zhou Y;Li C;Chen F;Chen J;Wang Y;Pan H;Wang D;Jin J
MYH9表达先前已被证明是实体瘤临床结果的独立预测因子。然而，MYH9表达在急性髓系白血病中的预后相关性仍不清楚。在这里，我们发现高MYH9表达者在女性中更常见，在M4形态中更常见。我们还发现MYH9高表达者的骨髓原始细胞百分比较低。此外，MYH9的过表达与较差的总生存率相关。值得注意的是，在高MYH9表达者中观察到不同的microRNA特征。这些结果也在使用已发表数据的AML患者的独立队列中得到验证。结论MYH9基因表达可作为AML患者总生存期的可靠预测指标。
MYH9 expression has previously been demonstrated as an independent predictor of clinical outcome in solid tumors. However, the prognostic relevance of MYH9 expression in acute myeloid leukemia is still unclear. Here, we found high MYH9 expressers were seen more frequently in females and more frequently in M4 morphology. We also found high MYH9 expressers had lower percentage of bone marrow blasts. In addition, overexpression of MYH9 was associated with an inferior overall survival. Notably, distinct microRNA signatures were seen in high MYH9 expressers. These results were also validated in an independent cohort of AML patients using the published data. In conclusion, gene of MYH9 expression might serve as a reliable predictor for overall survival in AML patients.