Untreated pediatric primitive neuroectodermal tumor in vivo:: Quantitation of taurine with MR spectroscopy
Untreated pediatric primitive neuroectodermal tumor in vivo:: Quantitation of taurine with MR spectroscopy
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DOI：
10.1148/radiol.2363040856
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发表时间：
2005-09-01
期刊：
影响因子：
19.7
通讯作者：
Blüml, S
中科院分区：
文献类型：
--
作者：
Kovanlikaya, A;Panigrahy, A;Blüml, S
目得：回顾性调查是否定量牛磺酸（Tau）浓度与质子磁共振（MR）光谱在体内提高分化的原始神经外胚层肿瘤（PNET）从其他常见的脑肿瘤在儿科patients.MATERIALS和METHODS：机构审查委员会批准了这一审查的临床数据，它是没有必要获得父母的同意。本研究符合HIPAA。在29例未经治疗的脑肿瘤患者（12例男孩和17例女孩;平均年龄6.5岁3.5岁）的术前MR成像检查中增加了单体素质子波谱检查; 13例患有PNTR，16例患有其他肿瘤。测定质子谱代谢物的绝对浓度（以毫摩尔/千克脑组织为单位）。结果：绝对Tau浓度的升高被证明是区分PNTR与其他肿瘤的最显著的代谢物（6.09 mmol/kg +/-2.24 vs 0.76 mmol/kg 0.95，P <0.001）。PNTR也表现出较高的Tau相对于胆碱的比率（1.21 +/- 0.48 vs 0.28 +/- 0.39，P < .001），Tau相对于肌酸的比率较高（1.28 +/- 0.44 vs 0.38 +/- 0.67，P < .001），N-乙酰天冬氨酸相对于胆碱的比例降低（0.20 +/- 0.20 vs 0.79 +/- 0.56，P < .001），以及增加的胆碱浓度（5.30 mmol/kg +/- 1.64 vs 3.08 mmol/kg +/- 2.53，P < .05）。Tau浓度范围从2.62至11.15 mmol/kg的个别患者与PNET.CONCLUSION：单体素定量H-1 MR波谱进行未经治疗的儿童脑肿瘤患者表明，Tau浓度显着升高PNETS和其他肿瘤的鉴别是有用的。(c)RSNA，2005年。
PURPOSE: To retrospectively investigate whether quantitation of taurine (Tau) concentrations with proton magnetic resonance (MR) spectroscopy in vivo improves the differentiation of primitive neuroectodermal tumors (PNET) from other common brain tumors in pediatric patients.MATERIALS AND METHODS: The institutional review board approved this review of clinical data; it was not necessary to obtain parental consent. This study was HIPAA compliant. Single-voxel proton spectroscopy was added to the preoperative MR imaging work-up of 29 patients (12 boys and 17 girls; mean age, 6.5 years 3.5) with untreated brain tumors; 13 had PNETs, and 16 had other tumors. Absolute concentrations (measured in millimoles per kilogram of brain tissue) of metabolites of the proton spectrum were determined. Student t tests were used for statistical comparisons.RESULTS: Elevated absolute Tau concentration proved to be the most significant metabolite in the differentiation of PNETs from other tumors (6.09 mmol/kg +/- 2.24 vs 0.76 mmol/kg 0.95, P < .001). PNETs also exhibited a higher ratio of Tau relative to choline (1.21 +/- 0.48 vs 0.28 +/- 0.39, P < .001), a higher ratio of Tau relative to creatine (1.28 +/- 0.44 vs 0.38 +/- 0.67, P < .001), a reduced a ratio of N-acetyl-aspartate relative to choline (0.20 +/- 0.20 vs 0.79 +/- 0.56, P < .001), and an increased choline concentration (5.30 mmol/kg +/- 1.64 vs 3.08 mmol/kg +/- 2.53, P < .05). Tau concentrations ranged from 2.62 to 11.15 mmol/kg in individual patients with a PNET.CONCLUSION: Single-voxel quantitative H-1 MR spectroscopy performed in patients with untreated pediatric brain tumors showed that the Tau concentration was significantly elevated in PNETs and was useful in the differentiation of PNETS from other tumors. (c) RSNA, 2005.