The pediatric nephrotic syndrome spectrum: clinical homogeneity and molecular heterogeneity.
The pediatric nephrotic syndrome spectrum: clinical homogeneity and molecular heterogeneity.
复制标题
小儿肾病综合征谱：临床同质性和分子异质性。
DOI：
10.1111/j.1399-3046.2004.00179.x
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Schachter,AsherD
中科院分区：
文献类型：
--
作者：
Schachter,AsherD
摘要：特发性肾病综合征是儿童最常见的肾小球疾病。肾移植后立即复发的肾病综合征是迅速的，导致移植物丢失率高，是肾病综合征最严重的形式。这篇综述讨论了儿童肾病综合征在疾病活动谱上的分子异质性。为儿童肾病综合征的分子治疗提供了一种模式，包括免疫介导和结构/遗传因素。
Abstract:Idiopathic nephrotic syndrome is the most common glomerular disorder of childhood. Recurrence of nephrotic syndrome immediately following renal transplantation is rapid, results in a high rate of graft loss, and represents the most severe form of nephrotic syndrome. This review discusses the molecular heterogeneity of pediatric nephrotic syndrome across the spectrum of disease activity. A schema is offered for a molecular approach to pediatric nephrotic syndrome, including immune‐mediated and structural/genetic factors.