Control of anterior pituitary cell excitability by calcium-activated potassium channels.
Control of anterior pituitary cell excitability by calcium-activated potassium channels.
复制标题
通过钙激活钾通道控制垂体前叶细胞的兴奋性。
DOI：
10.1016/j.mce.2017.06.003
复制
发表时间：
2018
影响因子：
4.1
通讯作者：
Shipston MJ
中科院分区：
文献类型：
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作者：
Shipston MJ
在垂体前叶内分泌细胞中，大（BK）、小（SK）和中（IK）电导钙激活钾通道是以细胞类型和环境特异性方式塑造细胞兴奋性的关键决定因素。事实上，这些通道被刺激或抑制细胞兴奋性的多种信号通路靶向。BK通道可以，矛盾的是，既促进电爆发，以及终止爆发和尖峰依赖于内在BK通道特性和接近电压门控的钙通道在生长激素，催乳素和促肾上腺皮质激素。相比之下，SK通道主要由从细胞内IP3敏感性钙库释放的钙激活，并介导包括促性腺激素细胞和促肾上腺皮质激素细胞在内的细胞中的膜超极化。IK通道主要表达在促肾上腺皮质激素细胞中，它们限制膜的兴奋性。未来的一个主要挑战是确定钙激活钾通道的细胞类型特异性分子组成，以及它们如何控制垂体前叶激素分泌以及其他钙依赖性过程。
In anterior pituitary endocrine cells, large (BK), small (SK) and intermediate (IK) conductance calcium activated potassium channels are key determinants in shaping cellular excitability in a cell type- and context-specific manner. Indeed, these channels are targeted by multiple signaling pathways that stimulate or inhibit cellular excitability. BK channels can, paradoxically, both promote electrical bursting as well as terminate bursting and spiking dependent upon intrinsic BK channel properties and proximity to voltage gated calcium channels in somatotrophs, lactotrophs and corticotrophs. In contrast, SK channels are predominantly activated by calcium released from intracellular IP3-sensitive calcium stores and mediate membrane hyperpolarization in cells including gonadotrophs and corticotrophs. IK channels are predominantly expressed in corticotrophs where they limit membrane excitability. A major challenge for the future is to determine the cell-type specific molecular composition of calcium-activated potassium channels and how they control anterior pituitary hormone secretion as well as other calcium-dependent processes.