Dissection of the signal for DNA methylation in the zeta-eta region of Neurospora.
Dissection of the signal for DNA methylation in the zeta-eta region of Neurospora.
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脉孢菌 zeta-eta 区域 DNA 甲基化信号的剖析。
DOI：
10.1101/sqb.1993.058.01.038
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Miao,V
中科院分区：
文献类型：
--
作者：
Selker,EU;Richardson,GA;Garrett-Engele,PW;Singer,MJ;Miao,V
遗传学家最喜欢的一些真核生物，如果蝇和酵母，没有检测到DNA甲基化。这使人认为甲基化是真核DNA上不重要的装饰。然而，现在已知DNA甲基化在小鼠中是必需的（Li等，1992和本卷）。DNA甲基转移酶基因的突变会阻碍胚胎发育。甲基化对发育至关重要的原因尚不清楚。因此，尽管DNA甲基化很重要，至少在某些生物中是如此，但我们对它在真核生物中的功能和控制仍然一无所知。
Some of geneticists' favorite eukaryotic organisms, such as Drosophila and yeasts, have no detectable DNA methylation. This tempts one to consider methylation an unimportant frill on eukaryotic DNA. It is now known, however, that DNA methylation is essential in mice (Li et al. 1992 and this volume). Mutations in the DNA methyltransferase gene block embryonic development. The reason that methylation is essential for development is unknown. Thus, although it is clear that DNA methylation is important, at least in some organisms, we remain largely in the dark both about its function and about its control in eukaryotes.