RNA motifs and combinatorial prediction of interactions, stability and localization of noncoding RNAs
RNA motifs and combinatorial prediction of interactions, stability and localization of noncoding RNAs
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DOI：
10.1038/s41594-018-0155-0
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发表时间：
2018-12-01
影响因子：
16.8
通讯作者：
Diederichs, Sven
中科院分区：
文献类型：
--
作者：
Gandhi, Minakshi;Caudron-Herger, Maiwen;Diederichs, Sven
虽然非编码RNA（ncRNA）的数量正在迅速增加，但对其分子功能的了解仍然滞后。确定特定的RNA基序，介导转录稳定性，相互作用和本地化可能有助于预测这些功能在新的转录本，并可能有潜在的影响ncRNA功能。在这里，我们回顾RNA基序，重点是最近的四项研究确定核保留基序，并讨论了有限的特异性短RNA基序和有效的功能预测所带来的挑战。未来的方法可能会成功地整合额外的部分序列为基础的属性的组合和合作效果。
Although the number of documented noncoding RNAs (ncRNAs) is rapidly increasing, knowledge of their molecular function is lagging behind. The identification of specific RNA motifs that mediate transcript stability, interactions and localization may aid in the prediction of these features in new transcripts and may have potential implications for ncRNA function. Here, we review RNA motifs, focusing on four recent studies identifying nuclear-retention motifs, and discuss the limited specificity of short-RNA motifs and the resulting challenge for effective functional prediction. Future approaches may succeed by integrating combinatorial and cooperative effects of additional partially sequence-based properties.