Staging of renal cell carcinoma: current progress and potential advances
Staging of renal cell carcinoma: current progress and potential advances
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DOI：
10.1016/j.pathol.2020.08.007
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发表时间：
2021-01-01
期刊：
影响因子：
4.5
通讯作者：
Egevad, Lars
中科院分区：
文献类型：
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作者：
Delahunt, Brett;Eble, John N.;Egevad, Lars
肾细胞癌（RCC）的正式分期分类于1978年首次提出，并于1978年被纳入国际抗癌联盟（UICC）最初发布的肿瘤、淋巴结、转移（TNM）系统。通过六个不同版本的UICC TNM分类，分级标准逐渐演变，最新版本于2016年发布。令人惊讶的是，从2009年到2016年的分类中，T类标准没有变化，尽管后来出版了一份勘误表，其中包含了美国癌症联合委员会出版的第八版TNM分类中的微小变化。局部肿瘤根据原发肿瘤的大小进行分期，TNM分类认为这些肿瘤的直径可能超过10 cm。这是不幸的，因为有很好的证据表明，对于透明细胞肾细胞癌，几乎所有直径7 cm的肿瘤，
Formal staging classifications for renal cell carcinoma (RCC) were first proposed in 1978 and were incorporated into the Tumour, Nodes, Metastases (TNM) system initially published by the Union Internationale Contre le Cancer (UICC) in 1978. There has been a gradual evolution of grading criteria through six separate editions of the UICC TNM Classification, with the latest edition being published in 2016. Somewhat surprisingly there were no changes to the T category criteria from the 2009 to the 2016 editions of the classification, although an erratum has subsequently been published that incorporated the minor changes included in the eighth edition of the TNM Classification published by the American Joint Committee on Cancer. Localised tumours are staged according to the size of the primary tumour, with the TNM classification recognising that these tumours may exceed 10 cm in diameter. This is unfortunate as there is good evidence to demonstrate that, for clear cell RCC, virtually all tumours 7 cm in diameter and a substantial proportion of tumours