Effects of magnesium sulfate on dynamic changes of brain glucose and its metabolites during a short-term forced swimming in gerbils
Effects of magnesium sulfate on dynamic changes of brain glucose and its metabolites during a short-term forced swimming in gerbils
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DOI：
10.1007/s00421-006-0374-7
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发表时间：
2007-04-01
影响因子：
3
通讯作者：
Cheng, Fu-Chou
中科院分区：
文献类型：
--
作者：
Cheng, Shiu-Min;Yang, Dar-Yu;Cheng, Fu-Chou
这项研究研究了镁对有意识的沙鼠在强迫游泳期间脑葡萄糖、乳酸、丙酮酸和镁水平动态变化的急性影响。沙鼠在15 min强制游泳前用生理盐水（对照组）和硫酸镁（90 mg kg(-1)，腹腔注射）进行预处理。脑透析液中葡萄糖、丙酮酸、乳酸和镁的基础水平分别为338+/-18、21+/-2、450+/-39和2.1+/-0.1μM，组间无显着差异。镁治疗组的镁水平略高（但并不显着）。然而，游泳后对照组的脑葡萄糖和丙酮酸水平分别下降至基础水平的约50%和60%（P = 0.01）。在强迫游泳期间，硫酸镁预处理立即使葡萄糖水平增加至基础水平的约140%，并将丙酮酸水平增加至基础水平的约150%（P = 0.01）。恢复30分钟后，葡萄糖和丙酮酸水平均恢复至基础水平。游泳期间对照组的乳酸水平增加至基础水平的约160%（P = 0.01），而硫酸镁预处理使乳酸水平降低至基础水平的130%（P = 0.01）。补充镁可能是有益的，因为它提供了额外的葡萄糖来源，并且还可以促进强迫运动期间和之后大脑中能量底物的恢复。为了达到最佳的身体表现，需要进一步研究镁补充剂的剂量。
This investigation examined the acute effects of magnesium on the dynamic changes of brain glucose, lactate, pyruvate and magnesium levels in conscious gerbils during forced swimming. Gerbils were pretreated with saline (control group) and magnesium sulfate (90 mg kg(-1), intraperitoneal injection) before a 15 min forced swimming period. The basal levels of glucose, pyruvate, lactate, and magnesium in brain dialysates were 338 +/- 18, 21 +/- 2, 450 +/- 39, and 2.1 +/- 0.1 mu M, respectively, with no significant difference between groups. Magnesium levels were found slightly higher (but not significant) in the magnesium-treated group. However, brain glucose and pyruvate levels in the control group decreased to about 50 and 60% of the basal level (P = 0.01) after swimming, respectively. Pretreatment with magnesium sulfate immediately increased glucose levels to about 140% of the basal level, and increased pyruvate levels to about 150% of the basal level during forced swimming (P = 0.01). Both glucose and pyruvate levels returned to the basal level after 30 min of the recovery. The lactate levels of the control group increased to about 160% of the basal level (P = 0.01) during swimming, whereas pretreatment with magnesium sulfate attenuated lactate levels to 130% of the basal level (P = 0.01). Magnesium supplementation may be beneficial because it provides an additional glucose source and may also promote the recovery of energy substrates in the brain during and after forced exercise. In order to achieve optimal physical performance, further investigation as to dosage of magnesium supplementation is needed.