INHIBITION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE TUMORIGENICITY IN MOUSE LUNG BY THE SYNTHETIC ORGANOSELENIUM COMPOUND, 1,4-PHENYLENEBIS(METHYLENE)SELENOCYANATE
INHIBITION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE TUMORIGENICITY IN MOUSE LUNG BY THE SYNTHETIC ORGANOSELENIUM COMPOUND, 1,4-PHENYLENEBIS(METHYLENE)SELENOCYANATE
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DOI：
10.1093/carcin/14.6.1111
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发表时间：
1993-06-01
期刊：
影响因子：
4.7
通讯作者：
HECHT, SS
中科院分区：
文献类型：
--
作者：
ELBAYOUMY, K;UPADHYAYA, P;HECHT, SS
通过在饮食中给予1，4-亚苯基双（亚甲基）硒氰酸酯（p-XSC），在雌性A/J小鼠中检查了5、10和15 p. p.m.（以硒计）p-XSC对烟草特异性4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁酮（NNK）诱导的肺肿瘤的化学预防作用。以相同的方式给予亚硒酸钠（5 p. p.m.硒），以与p-XSC进行比较。在腹膜内注射溶于0.1 ml盐水的10 μ mol NNK前1周，给小鼠喂食含硒化合物的实验饮食，并在整个实验过程中直至终止，即致癌物给药后16周。不同饮食组小鼠的体重没有显著差异。p-XSC显著抑制肺肿瘤多样性，从对照组的每只小鼠7.6个肿瘤到分别给予5、10和15 p. p.m.硒的动物中的每只小鼠4.1、3.3和1.8个肿瘤。相比之下，5 p. p.m.亚硒酸钠对肺肿瘤诱导没有保护作用。这项研究的结果清楚地表明，含硒化合物的结构是重要的，在确定其作为化学预防剂的功效。
The chemopreventive effect of 5, 10 and 15 p.p.m. (as selenium) of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) on lung tumor induction by the tobacco-specific 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was examined in female A/J mice by administering p-XSC in the diet. Sodium selenite (5 p.p.m. selenium) was given in the same manner for comparison with p-XSC. Mice were fed experimental diets containing the selenium compounds 1 week before i.p. injection of 10 mumol NNK in 0.1 ml saline and throughout the experiment until termination, 16 weeks after carcinogen administration. Body weights of the mice in the different dietary groups did not differ significantly. p-XSC significantly inhibited lung tumor multiplicity from 7.6 tumors per mouse in the control group to 4.1, 3.3 and 1.8 tumors per mouse in animals given 5, 10 and 15 p.p.m. of selenium respectively. In contrast, 5 p.p.m. sodium selenite had no protective effect against lung tumor induction. The results of this study clearly indicate that the structure of selenium-containing compounds is important in determining their efficacy as chemopreventive agents.