High maternal selenium levels are associated with increased risk of congenital heart defects in the offspring
High maternal selenium levels are associated with increased risk of congenital heart defects in the offspring
复制标题
母亲体内硒含量高与后代先天性心脏病风险增加有关
DOI：
10.1002/pd.5551
复制
发表时间：
2019-09-12
影响因子：
3
通讯作者：
Liu, Zhen
中科院分区：
文献类型：
--
作者：
Guo, Yixiong;Yu, Ping;Liu, Zhen
目的探讨母亲发硒或脐血硒水平与婴儿先天性心脏病（CHD）的关系。方法采用以医院为基础的病例对照研究方法，对2010 - 2014年的样本进行分析。采用电感耦合等离子体质谱法（ICP-MS）测定母体头发和胎儿脐带血清中的硒水平。资料来源于婴幼儿CHD病例。采用Logistic回归分析母亲硒暴露与胎儿CHD的独立相关性。结果888例孕妇纳入研究。母亲头发中硒含量的中位数（四分位距）在对照组和CHD组中相似。母亲发硒浓度增加与后代CHD之间存在显著相关性（校正比值比[aOR] 3.57，95%CI，1.90-6.70）。这种关联存在于所有CHD组中，包括间隔缺损、圆锥动脉干缺损、左心室流出道梗阻、右心室流出道梗阻和肺静脉回流异常。结论母亲硒水平高与胎儿CHD的发生密切相关。
Objective To examine whether maternal hair or cord blood selenium levels are associated with infant congenital heart defects (CHDs). Method A hospital-based case-control study was performed with samples collected from 2010 to 2014. Selenium levels in maternal hair and fetal cord serum were measured using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Data from medical records of infants with CHDs were collected. Logistic regression analysis was employed to examine the independent association between maternal selenium exposure and fetal CHD. Results In total, 888 pregnant women were included in this study. Median (interquartile range) selenium levels in of maternal hair was similar in the control and CHD group. A significant association was detected between increased maternal hair selenium concentration and CHDs in offspring (adjusted odds ratio [aOR] 3.57, 95 %CI, 1.90-6.70). The association was present in all CHD groups, including septal defects, conotruncal defects, left ventricular outflow tract obstruction, right ventricular outflow tract obstruction, and anomalous pulmonary venous return. Conclusion High maternal selenium level is significantly associated with the occurrence of fetal CHD.