SEX-DIFFERENCES IN SALT PREFERENCE AND TASTE REACTIVITY IN RATS
SEX-DIFFERENCES IN SALT PREFERENCE AND TASTE REACTIVITY IN RATS
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DOI：
10.1016/0361-9230(93)90061-f
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发表时间：
1993-01-01
影响因子：
3.8
通讯作者：
HAVENS, M
中科院分区：
文献类型：
--
作者：
FLYNN, FW;SCHULKIN, J;HAVENS, M
先前的研究表明，雌性大鼠消耗的氯化钠（NaCl）明显多于年龄匹配的雄性大鼠。味觉对这种性别差异的贡献在下面的实验中进行了研究。在实验1中，雌性大鼠表现出更高的两瓶偏好NaCl范围从0.03 M至1.0 M比年龄匹配的男性。接下来，为了确定动物的性别是否改变了对NaCl的味觉敏感性，通过口内输注（0.8ml）NaCl（0.03M，0.05M）引起的味觉反应性应答。在年龄匹配的雄性和雌性Sprague-Dawley大鼠中测量了1.5 M、0.3 M和1.0 M）。连续几天以浓度递增顺序口内输注NaCl。在口内输注期间，将动物的口腔运动味觉反应性反应录像并随后分析以确定摄食和厌恶反应的数量。口内输注0.15 M和0.3 M NaCl引起可靠的摄食反应和1.0 M NaCl更厌恶的反应，女性比男性。因为在所有雌性大鼠比雄性大鼠表现出更高偏好的浓度下未发现味觉反应差异，味觉敏感性的变化有助于但似乎不能完全解释雌性大鼠对NaCl的偏好。
Previous studies have shown that female rats consume significantly more sodium chloride (NaCl) than do age-matched males. The gustatory contribution to this sex difference was examined in the following experiments. In Experiment 1, female rats demonstrated a higher two-bottle preference for NaCl ranging from 0.03 M to 1.0 M than did age-matched males. Next, to determine if the animal's sex modified gustatory sensitivity for NaCl, taste reactivity responses elicited by intraoral infusions (0.8 ml) of NaCl (0.03 M, 0. 1 5 M, 0.3 M, and 1.0 M) were measured in age-matched male and female Sprague-Dawley rats. Intraoral infusions of NaCl were administered in ascending concentration order on successive days. During the intraoral infusion, the animal's oral motor taste reactivity responses were videotaped and subsequently analyzed to determine the number of ingestive and aversive responses. Intraoral infusions of 0.15 M and 0.3 M NaCl elicited reliably more ingestive responses and 1.0 M NaCl more aversive responses in females than in males. Because differences in taste reactivity were not found for all those concentrations for which female rats showed a higher preference than did males, changes in gustatory sensitivity contributes to, but does not appear to fully account for the female rats' preference for NaCl.