Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells.
Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells.
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DOI:
10.1038/nn.2895
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发表时间:
2011-08-07
影响因子:
25
通讯作者:
Lee A
中科院分区:
文献类型:
--
作者:
Gregory FD;Bryan KE;Pangršič T;Calin-Jageman IE;Moser T;Lee A
Harmonin is a scaffolding protein required for normal mechanosensory function in hair cells. Here, we describe a novel presynaptic association of harmonin and Cav1.3 Ca2+ channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.
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