Real-time microscopic visualization of tissue response to laser thermal therapy
Real-time microscopic visualization of tissue response to laser thermal therapy
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DOI：
10.1117/1.2714027
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发表时间：
2007-03-01
影响因子：
3.5
通讯作者：
Bouma, Brett E.
中科院分区：
文献类型：
--
作者：
Vakoc, Benjamin J.;Tearney, Guillermo J.;Bouma, Brett E.
我们提出了可视化生物样品对激光诱导加热的动态响应的方法。我们的方法利用光学频域成像来检测、空间定位和监控活跃组织变性区域内出现的独特的动态特征。由于该信息与高分辨率(类似于10微米)的横截面图像精确配准，因此可以根据预先存在的形态绘制热破坏组织的区域。使用体外猪食道标本，我们证明了激光热损伤的程度和演变可以实时评估。(C)2007年，光学仪器工程师学会。
We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely registered with high-resolution (similar to 10 mu m) cross sectional images, regions of thermally destroyed tissue can be mapped in relation to pre-existing morphology. Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time. (C) 2007 Society of Photo-Optical Instrumentation Engineers.