Clinicopathological characteristics of primary squamous cell carcinoma of breast
Clinicopathological characteristics of primary squamous cell carcinoma of breast
复制标题
乳腺癌原发性鳞状细胞癌的临床病理特征
DOI：
10.3760/cma.j.issn.1006-9801.2010.03.006
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发表时间：
2016
影响因子：
1.4
通讯作者：
Fu, Li
中科院分区：
文献类型：
--
作者：
Lang, Ronggang;Shen, Beibei;Zhang, Xinmin;Fu, Li
目的探讨乳腺原发性鳞状细胞癌（PSCCB）的临床病理及生化特征。方法回顾性分析16例原发性乳腺鳞状细胞癌患者的临床资料。对12例有随访资料的乳腺癌患者进行ER、PR、C-erbB-2、HCK、Ki-67的检测。结果PSCCB是一种非常罕见的肿瘤，占我院28年（1981-2008年）乳腺癌的0.8%。年龄25 ~ 72岁，中位年龄49岁。所有患者均行手术治疗。7例患者有腋窝淋巴结转移。3例死于转移和肿瘤复发，肿瘤多为ER阴性，但多为高分子细胞角蛋白（HCK）表达。病理证实为PSCCB。预后是有争议的。标准治疗应在未来进行研究和推荐。
关键词：
乳腺肿瘤;癌，鳞状细胞;肿瘤，第二原发性
Objective To investigate the clinicopathologic and immunohistochemicalcharacteristics of primary squamous cell carcinoma of the breast(PSCCB). Methods Sixteen patients with primary squamous cell carcinoma of the breast were retrospectively reviewed. Twelve cases with a follow-up information were evaluated for ER, PR, C-erbB-2, HCK, Ki-67 expression. Results PSCCB is a very rare neoplasm,constituting 0.8 % of all breast carcinoma over 28 years(1981-2008) in our hospital. The patients age varied from 25 to 72, median age is 49 years old. All patients received operative treatment. Seven patients had metastatic disease in axillary lymph nodes. Three patients died from metastases and tumour recurrence.Tumors were usually ER-negative, but most cases showed high molecular cytokeratin (HCK) expression.Conclusion In terms of the clinical feature, there were no differences between the PSCCB and the other breast cancer. PSCCB could be confirmed by pathology. The prognosis is in controversial. Standard therapy should be studied and recommended in future.
Key words:
Breast neoplasms; Carcinoma, squamous cell; Neoplasms, second primary