Nanomedicine applications in the treatment of breast cancer: current state of the art.
Nanomedicine applications in the treatment of breast cancer: current state of the art.
复制标题
纳米医学在治疗乳腺癌中的应用：当前的艺术状态。
DOI：
10.2147/ijn.s123437
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发表时间：
2017
影响因子：
8
通讯作者：
Wong HL
中科院分区：
文献类型：
--
作者：
Wu D;Si M;Xue HY;Wong HL
乳腺癌是世界范围内女性最常见的恶性肿瘤，但目前的药物治疗远未达到最佳水平，乳腺癌患者的高死亡率表明了这一点。纳米医学是乳腺癌治疗的一种有前途的选择。纳米医学产品如Doxil®和Abraxane®已经广泛用于乳腺癌辅助治疗，并取得了良好的临床效果。然而，这些产品最初设计用于一般抗癌目的，而不是专门用于乳腺癌治疗。随着对乳腺癌分子生物学的深入了解，近年来开发了许多新的有前途的纳米治疗策略和装置。本文首先综述了目前乳腺癌的治疗和纳米药物在临床应用的最新进展，然后讨论了乳腺癌纳米药物设计的最新重要趋势，包括被动和主动靶向癌细胞、乳腺癌干细胞靶向、基于肿瘤微环境的纳米治疗和耐药乳腺癌的联合纳米治疗。研究人员可以从这些策略中获得启发，设计和开发更适合乳腺癌的纳米药物，以进一步提高癌症特异性，抗肿瘤作用，抗转移作用和耐药性逆转作用。
Breast cancer is the most common malignant disease in women worldwide, but the current drug therapy is far from optimal as indicated by the high death rate of breast cancer patients. Nanomedicine is a promising alternative for breast cancer treatment. Nanomedicine products such as Doxil® and Abraxane® have already been extensively used for breast cancer adjuvant therapy with favorable clinical outcomes. However, these products were originally designed for generic anticancer purpose and not specifically for breast cancer treatment. With better understanding of the molecular biology of breast cancer, a number of novel promising nanotherapeutic strategies and devices have been developed in recent years. In this review, we will first give an overview of the current breast cancer treatment and the updated status of nanomedicine use in clinical setting, then discuss the latest important trends in designing breast cancer nanomedicine, including passive and active cancer cell targeting, breast cancer stem cell targeting, tumor microenvironment-based nanotherapy and combination nanotherapy of drug-resistant breast cancer. Researchers may get insight from these strategies to design and develop nanomedicine that is more tailored for breast cancer to achieve further improvements in cancer specificity, antitumorigenic effect, antimetastasis effect and drug resistance reversal effect.