In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B
In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B
复制标题
两性霉素 B 和脂质体包裹的两性霉素 B 的体外抗真菌活性
DOI：
10.1128/aac.25.3.387
复制
发表时间：
1984
影响因子：
4.9
通讯作者：
R. Juliano
中科院分区：
文献类型：
--
作者：
R. Hopfer;K. Mills;R. Mehta;G. Lopez;V. Fainstein;R. Juliano
The in vitro activities of liposome-encapsulated amphotericin B and free amphotericin B against Candida albicans 336 were comparable. Amphotericin B concentrations 12-fold and greater than 50-fold higher were required to kill the same organism when cholesterol and ergosterol were incorporated into the liposomes. The addition of cholesterol to liposomes caused a significant increase in the minimal fungicidal concentration of amphotericin B in 7 of 19 other yeast strains tested, whereas ergosterol caused an increase in 18 of the 19 strains.
