Possible Association Between OPRM1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms
Possible Association Between OPRM1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms
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DOI：
10.1111/j.1530-0277.2011.01714.x
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发表时间：
2012-07-01
影响因子：
3.2
通讯作者：
Preuss, Ulrich W.
中科院分区：
文献类型：
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作者：
Koller, Gabriele;Zill, Peter;Preuss, Ulrich W.
背景：已有研究表明阿片受体在酒精强化和酒精依赖（AD）风险中起重要作用。本文报道了μ阿片受体（OPRM 1）A118 G（Asn 40 Asp，rs 1799971）多态性在酒精中毒发生中的作用。方法我们采用卡方统计法调查了从德国住院机构招募的1,845名酒精依赖受试者和1,863名对照者的μ阿片受体（OPRM 1）多态性。结果在隐性（AA vs. GA/GG）和共显性（AA vs. GA）遗传模型中检测到OPRM变异与AD之间的关联（p = 0.022）。OPRM变体与DSM-IV标准努力减少或不能减少之间存在关联（p = 0.047），但在多次检验校正后，这并不显著。结论：结果表明，这种功能性OPRM变异与AD的风险相关，这些发现适用于更严重的AD，虽然这种关联只是名义上的显着。
Background Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism. Methods We investigated a total number of 1,845 alcohol-dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu-opioid receptor (OPRM1) polymorphism using chi-square statistics. Results An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co-dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM-IV criterion efforts to cut down or could not (p = 0.047) was found, but this did not remain significant after the correction for multiple testing. Conclusions The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant.