Metabolic Complications in Cardiac Aging.
Metabolic Complications in Cardiac Aging.
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DOI：
10.3389/fphys.2021.669497
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发表时间：
2021
影响因子：
4
通讯作者：
Drosatos K
中科院分区：
文献类型：
--
作者：
Sithara T;Drosatos K
衰老是一个可能伴随损害心脏功能的分子和细胞改变的过程。尽管其他代谢性疾病在老年人群中患病率增加，例如糖尿病、血脂异常和高血压，但与心血管并发症有关；衰老相关心肌病有一些独特的特征。健康的心脏氧化脂肪酸、葡萄糖、乳酸、酮体和氨基酸以产生能量。生理条件下，心肌线粒体主要利用脂肪酸和碳水化合物生成ATP，其中70%来源于脂肪酸氧化(FAO)。然而，随着葡萄糖氧化的增加，营养物质在 ATP 合成中的相对贡献在衰老的心脏中发生了变化，而脂肪酸的消耗却增加了。心脏衰老还与线粒体丰度和功能受损有关，导致活性氧（ROS）积累和氧化信号激活，最终导致线粒体进一步损伤和心脏功能恶化。本综述总结了心脏衰老病理生理学的主要组成部分，涉及心脏代谢、线粒体功能和影响心脏功能的全身代谢变化。
Aging is a process that can be accompanied by molecular and cellular alterations that compromise cardiac function. Although other metabolic disorders with increased prevalence in aged populations, such as diabetes mellitus, dyslipidemia, and hypertension, are associated with cardiovascular complications; aging-related cardiomyopathy has some unique features. Healthy hearts oxidize fatty acids, glucose, lactate, ketone bodies, and amino acids for producing energy. Under physiological conditions, cardiac mitochondria use fatty acids and carbohydrate mainly to generate ATP, 70% of which is derived from fatty acid oxidation (FAO). However, relative contribution of nutrients in ATP synthesis is altered in the aging heart with glucose oxidation increasing at the expense of FAO. Cardiac aging is also associated with impairment of mitochondrial abundance and function, resulting in accumulation of reactive oxygen species (ROS) and activation of oxidant signaling that eventually leads to further mitochondrial damage and aggravation of cardiac function. This review summarizes the main components of pathophysiology of cardiac aging, which pertain to cardiac metabolism, mitochondrial function, and systemic metabolic changes that affect cardiac function.
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影响因子：
6.1
作者：
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通讯作者：
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影响因子：
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Rabinovitch PS
DOI：
10.1097/mco.0b013e3282f0dbfb
发表时间：
2007-11-01
影响因子：
3.1
作者：
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