Palladium(II)-Catalyzed Direct Intermolecular Alkenylation of Chromones
Palladium(II)-Catalyzed Direct Intermolecular Alkenylation of Chromones
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DOI：
10.1021/ol2018278
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发表时间：
2011-08-19
期刊：
影响因子：
5.2
通讯作者：
Hong, Sungwoo
中科院分区：
文献类型：
--
作者：
Kim, Donghee;Hong, Sungwoo
发展了一种新的高效的色酮烯基化反应，通过钯（II）催化的C-H官能化反应。新戊酸与Cu（OAc）（3）/Ag 2CO 3的使用在色酮与烯烃配对物的交叉偶联中提供了上级反应性。这种方法代表了一个显着的进步，现有的两步法，并提供了各种3-乙烯基色酮衍生物，这是特权的结构，在许多生物活性化合物和通用的合成积木。
A new efficient method for the direct alkenylation of chromones via a palladium(II)-catalyzed C-H functionalization reaction was developed. The use of pivalic acid with Cu(OAc)(3)/Ag2CO3 provided superior reactivity in the cross-coupling of chromones with alkene partners. This approach represents a significant advance over the existing two-step method and afforded various 3-vinylchromone derivatives, which are privileged structures in many biologically active compounds and versatile synthetic building blocks.